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p38 mitogen-activated protein kinases
| Cat.No. | Product Name | Feedback | Added |
|---|---|---|---|
| S1574 | BIRB 796 (Doramapimod) | Nov 2010 | |
| BIRB 796 (Doramapimod) a small molecule of p38 MAPK inhibitor with Kd of 0.1 nM is available at Selleck. | |||
| S1494 | LY2228820 | Sep 2010 | |
| LY2228820 is a novel and potent p38MAPK inhibitor (the IC50 for p38αMAPK and p38βMAPK were 7 nM and 3 nM, respectively). | |||
| S2726 | PH-797804 | Dec 2011 | |
| PH-797804 is a highly selective, potent, and ATP-competitive p38 MAP kinase inhibitor with an IC50 of 2.3 nM. | |||
| S1077 | SB 202190 |  | Jun 2009 |
| P38 MAP(mitogen activated protein) Kinase inhibitor. | |||
| S1076 | SB 203580 | | Jun 2009 |
| SB 203580 is a potent inhibitor of LPS-induced cytokine synthesis in the human monocyte cell line THP-1 (IC50 = 50-100 nM). | |||
| S1527 | Vinorelbine (Navelbine) | Oct 2010 | |
| Vinorelbine (Navelbine) is the first 5´NOR semi-synthetic vinca alkaloid and exerts its activity through the MAPK (p38) pathway with median IC90 and IC50 of 15.5 and 2.3 μM. | |||
| S6005 | VX-702 | Apr 2009 | |
| VX-702 is a P38 MAPK inhibitor , IL-6, IL-1β and TNFα (IC50 = 59, 122 and 99 ng/ml, respectively) | |||
| S1458 | VX-745 | Aug 2010 | |
| VX-745 is a lead anti-inflammatory candidate, p38 MAPK inhibitor (IC50=10 nM) for the treatment of Rheumatoid arthritis (RA). | |||
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Customer's Feedback
| Dongfeng Chen, The Rausing Lab |
| "Your product U0126(Cat.NO S1102) works well in our experiments. I hope I can get more excellent products from your company in future." |
| R.B. Cambridge |
| "I have used the chemical that I bought from you(Selleck,PTC-124) and it worked well.So we will eventually be ordering more." |
| Zhenghe John Wang Assistant Professor, Case Western Reserve University |
| "We have purchased LBH-589, Saha and MS-275 from you and they all worked well." |
| Jenny Sun |
| "We used the LBH-589 in our experiments. The compound is easy to use with excellent reproducibility." |
| Yu Wang, Harvard University |
| "The GDC0449 compound worked very well. The results in my hands are equally good as what's been published. Thanks for this great resource for our research." |
| Dung-Fang Lee |
| "Based on our preliminary data, I found MLN8237 and VX-680 have good effects in inhibiting Aurka-maintaining ESC self-renewal in mouse ES cells." |
Latest Catalog
| May 2010 Selleck Latest Catalog |  |
