Syk

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Syk Inhibitors (7)

water-soluble

Cat.No. Product Name Information Product Citations Customer Reviews
S2194 R406 R406 is a potent Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 1.
  • Immunity, 2014, 40(3):389-99
  • J Clin Invest, 2014, 124(11):5074-84
  • Blood, 2013, 122(4):580-9
S2206 R788 (Fostamatinib) Disodium R788 (Fostamatinib) disodium, a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.
S1533 R406 (free base) R406 (free base) is a potent Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 1.
  • Nat Immunol, 2013, 14(12):1247-55
  • Clin Cancer Res, 2012, 19(3):586-97
  • UVIC, 2013, Meritxell Aguiló García
S8032 PRT062607 (P505-15, BIIB057) HCl PRT062607 (P505-15) HCl is a novel, highly selective Syk inhibitor with IC50 of 1 nM, >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.
  • Exp Dermatol, 2014, 10.1111/exd.12552
S2625 Fostamatinib (R788) Fostamatinib (R788), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.
  • Pharm Res, 2014, 31(11):3060-72
  • UVIC, 2013, Meritxell Aguiló García
S7523 Entospletinib (GS-9973) Entospletinib (GS-9973) is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM. Phase 2.
S3026 Piceatannol Piceatannol, a natural stilbene, is a selective Syk inhibitor and ~10-fold selectivity versus Lyn.
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