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S1009
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BEZ235 (NVP-BEZ235) |
BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM. |
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S1105
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LY294002 |
LY294002 is a PI3K inhibitor for p110α, p110δ and p110β with IC50 of 0.5 μM, 0.57 μM and 0.97 μM, respectively. |
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S1065
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GDC-0941 |
GDC-0941 is a potent inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 3 nM, 33 nM, 3 nM and 75 nM, respectively. |
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S2226
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CAL-101 (GS-1101) |
CAL-101 is a selective PI3K class I inhibitor of p110δ with IC50 of 2.5 nM. |
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S2247
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BKM120 (NVP-BKM120) |
BKM120 is a selective PI3K inhibitor of p110α, p110β, p110δ and p110γ with IC50 of 52-99 nM, 166 nM, 116 nM and 262 nM, respectively. |
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S7028
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IPI-145 (INK1197) |
IPI-145 (INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM. |
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S2638
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NU7441 (KU-57788) |
NU7441 is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM. |
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S2814
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BYL719 |
BYL719 strongly and selectively inhibits PI3Kα. |
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S8002
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GSK2636771 |
GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor. |
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S2870
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TG 100713 |
TG 100713 is a PI3K inhibitor for PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively. |
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S2759
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PI3K/HDAC InhibitorⅠ |
PI3K/HDAC Inhibitor I is a dual PI3K and HDAC inhibitor for PI3Kɑ, HDAC1, HDAC2, HDAC3 and HDAC10 with IC50 of 19 nM, 1.7 nM, 5 nM, 1.8 nM and 2.8 nM, respectively. |
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S2767
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3-Methyladenine |
3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM, respectively. |
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S1219
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YM201636 |
YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM. |
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S2758
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Wortmannin |
Wortmannin is a multi-target inhibitor of MLCK and PI3K with IC50 of 170 nM and 3 nM, and also potentlt inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM (less sensitive to ATR with IC50 of 1.8 μM). |
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S2749
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NVP-BGT226 |
NVP-BGT226 is a novel dual PI3K/mTOR inhibitor with IC50 of 1 nM. |
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S2802
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BAY80-6946 |
BAY 80-6946 is a potent and highly selective reversible PI3K inhibitor for PI3Kα and PI3Kβ with IC50 of 0.469 nM and 3.72 nM, respectively. |
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S2743
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PF-04691502 |
PF-04691502 is an ATP-competitive, selective inhibitor of PI3K(α/β/δ/γ)/mTOR with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM, also inhibits Akt phosphorylation on T308/S473 with IC50 of 7.5 nM/3.8 nM. |
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S2739
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PKI-402 |
PKI-402 is a potent dual PI3K/mTOR inhibitor targeting PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and mTOR with IC50 of 2 nM, 7 nM, 16 nM, 14 nM, and 3 nM, respectively. |
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S2699
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CH5132799 |
CH5132799 exhibits a strong inhibitory activity especially against PI3Kα with IC50 of 14 nM and also inhibits mTOR with IC50 of 1.6 µM. |
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S2696
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GDC-0980 (RG7422) |
GDC-0980 (RG7422) is a potent, selective inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 5 nM, 27 nM, 7 nM, and 14 nM, and also a mTOR inhibitor with Ki of 17 nM. |
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S2671
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AS-252424 |
AS-252424 is a novel, potent and selective inhibitor of PI3Kγ with IC50 of 33 nM. |
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S2681
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AS-604850 |
AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM. |
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S2682
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CAY10505 |
CAY10505 is a PI3Kγ inhibitor with IC50 of 30 nM. |
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S2658
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GSK2126458 |
GSK2126458 is a highly selective and potent inhibitor of p110α, p110β, p110γ, p110δ, mTORC1 and mTORC2 with Ki of 0.019 nM, 0.13 nM, 0.024 nM, 0.06 nM, 0.18 nM and 0.3 nM, respectively. |
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S2636
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A66 |
A66 is a potent and specific p110α inhibitor with IC50 of 32 nM. |
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S2628
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PF-05212384 (PKI-587) |
PKI-587 is a highly potent dual inhibitor of PI3Kα, PI3Kγ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM, respectively. |
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S2227
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PIK-294 |
PIK-294 is a highly potent and selective p110δ inhibitor with IC50 of 10 nM. |
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S2207
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PIK-293 |
PIK-293 is a PI3-K inhibitor for p110α, p110β, p110δ and p110γ with IC50 of 100 μM, 25 μM, 0.24 μM and 10 μM, respectively. |
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S1523
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XL765 (SAR245409) |
XL765 is a dual inhibitor of mTOR/PI3k for mTOR, p110α, p110β, p110γ and p110δ with IC50 of 157 nM, 39 nM, 113 nM, 9 nM and 43 nM, respectively. |
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S1489
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PIK-93 |
PIK-93 is a novel and potent inhibitor of PI3Kγ and PI4KIIIβ with IC50 of 16 nM and 19 nM, respectively. |
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S1462
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AZD6482 |
AZD6482 is an inhibitor of PI3Kβ with IC50 of 21 nM. |
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S1410
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AS-605240 |
AS-605240 is a novel, potent and selective PI3Kγ inhibitor with IC50 of 8 nM. |
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S1360
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GSK1059615 |
GSK1059615 is a novel and dual inhibitor of PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR with IC50 of 0.4 nM, 0.6 nM, 2 nM, 5 nM and 12 nM, respectively. |
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S1352
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TG100-115 |
TG100-115 is a potent and dual selective inhibitor for PI3Kγ and PI3Kδ with IC50 of 83 nM and 235 nM, respectively. |
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S1268
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IC-87114 |
IC-87114 is a selective inhibitor of PI3Kδ with IC50 of 0.5 μM. |
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S1205
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PIK-75 |
PIK-75 is a selective and competitive inhibitor of p110α with IC50 of 5.8 nM and also potently inhibits DNA-PK with IC50 of 2 nM. |
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S1187
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PIK-90 |
PIK-90 is a potent and cell permeable inhibitor of p110α, p110β, p110γ and p110δ with IC50 of 11 nM, 350 nM, 18 nM and 58 nM, respectively. |
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S1169
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TGX-221 |
TGX-221 is a potent, selective PI3K inhibitor for p110β with IC50 of 8.5 nM. |
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S1118
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XL147 |
XL147 (SAR245408) is a selective and reversible class I PI3K inhibitor for wild type and mutant p110α with IC50 of 40 nM and 40 nM, respectively. |
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S1072
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ZSTK474 |
ZSTK474 is a potent pan-class I PI3K inhibitor with IC50 of 37 nM. |
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S1038
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PI-103 |
PI-103 is a potent, ATP-competitive PI3K inhibitor of DNA-PK, p110α, mTORC1, PI3KC2β, p110δ, mTORC2, p110β, and p110γ with IC50 of 2 nM, 8 nM, 20 nM, 26 nM, 48 nM, 83 nM, 88 nM and 150 nM, respectively. |
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