Phosphoinositide 3 kinase

Cat.No.	Product Name	Added

S2636	A66	Jul 2011
A66 is a highly specific and selective p110α inhibitor with IC50 of 32,30 and 43 nM for p110α, p110α/E545K, p110α/H1047R, respectively.

S2671	AS-252424	Aug 2011
AS-252424 is a potent and selective PI3k γ inhibitor with IC50 of 33 and 935 nM for PI3Kγ and PI3Kα, respectively.

S2681	AS-604850	Aug 2011
AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 0.25, >20, >20, and 4.5 µM for the human recombinant γ, δ, β, and α isoforms, respectively.

S1410	AS-605240	Jul 2010
AS-605240 is a PI3K γ inhibitor (IC50 at 8 nM).

S1462	AZD6482	Aug 2010
AZD6482 is a PI3Kβ inhibitor (IC50=0.021μM) used in antithrombotic therapy.

S1009	BEZ235 (NVP-BEZ235)	Apr 2009
BEZ235 (NVP-BEZ235) is a dual ATP-competitive phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitor with an IC50 of 4, 5, 7 and 75 nM for p110α, p110γ, p110δ and p110β, respectively.

S2247	BKM120 (NVP-BKM120)	May 2011
BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor.

S2226	CAL-101	Apr 2011
CAL-101 is a potent PI3K p110δ inhibitor with an IC50 of 65 nM.

S2682	CAY10505	Aug 2011
CAY10505 is a potent PI3Kγ inhibitor with an IC50 of 30 nM.

S2699	CH5132799	Nov 2011
CH5132799 is a novel and selective class I PI3K inhibitor with IC50 of 0.014, 0.12, 0.5, 0.036, 5.3 and 1.6 μM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, PI3K C2β and mTOR, respectively.

S2675	D-106669	Aug 2011
D-106669 is a highly selective PI3K inhibitor with a submicromolar inhibition.

S2676	D-87503	Aug 2011
D-87503 is a potent PI3K/Akt/mTOR signaling pathway inhibitor with IC50 of 62nM and 0.76μM for PI3K and Erk2, respectively.

S1065	GDC-0941	Jun 2009
GDC-0941 is an inhibitor of Class I PI3 Kinase,p110a IC50=0.003uM,U87MG IC50=0.95μM.

S2696	GDC-0980 (RG7422)	Nov 2011
GDC-0980 (RG7422) is a selective, dual PI3 Kinase and mTOR Kinase inhibitor with IC50 of 5, 27, 7, and 14 nM for PI3Kα, β, δ, and γ, respectively.

S1360	GSK1059615	Jun 2010
GSK1059615 is a pan-PI3K reversible inhibitor,IC50:PI3Kα(0.4 nM), β (0.6 nM),γ (5 nM),δ (2 nM) and mTOR(12 nM).

S2658	GSK2126458	Aug 2011
GSK2126458 is a highly potent PI3K and mTOR inhibitor with an app Ki of 19 pM for PI3K.

S1268	IC-87114	Jun 2010
IC-87114 was the first isoform-selective PI3K inhibitor : p110δ(IC50 = 0.13 µM) vs. p110α(IC50 = 200 µM), p110β(IC50 = 16 µM) and p110γ(IC50 = 61 µM).

S1105	LY294002	Aug 2009
PI3k inhibitor (cell IC50 about 10 μM) and a casein kinase II inhibitor.

S2638	NU7441	Aug 2011
NU7441 is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 0.01, 1.7 and 5 μM for DNA-PK, mTOR and PI 3-K, respectively.

S2743	PF-04691502	Jan 2012
PF-04691502 is a potent and selective dual PI3K/mTOR inhibitor to phosphorylation of AKT T308 and AKT S473 with IC50 of 7.5 and 3.8 nM, respectively.

S1038	PI-103	Apr 2009
PI-103 is a potent, cell-permeable, ATP-competitive PI3K family members inhibitor with IC50 of 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γ, respectively.

S2207	PIK-293	Feb 2011
PIK-293 is a PI3-K inhibitor.PIK-293 inhibit the p110α, p110β, p110δ, and p110γ with IC50 of 100uM,25uM,0.24uM,and 10uM.

S2227	PIK-294	Apr 2011
PIK-294 is a highly selective p110 inhibitor with an IC50 of 3 nM.

S1187	PIK-90	Apr 2010
PIK-90 is a PI3K inhibitor,IC50=11, 350, 18, and 58 for p110 α, β, γ and δ isoforms.

S1489	PIK-93	Sep 2010
PIK-93 is a PI4KIIIβinhibitor (IC50 at 19 nM).

S2739	PKI-402	Nov 2011
PKI-402 is a selective, reversible, ATP-competitive, equipotent class I phosphatidylinositol 3-kinases (PI3K) inhibitor with IC50 of 1, 7, 16 and 14 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively.

S2628	PKI-587	Jul 2011
PKI-587 is a highly potent dual PI3K/mTOR kinase inhibitor with IC50 of 0.4 nM and <0.1 μM for PI3K-α and mTOR, respectively.

S2622	PP121	Jun 2011
PP121 is a multitargeted dual receptor tyrosine kinases inhibitor with IC50 of 0.052, 1.4, 0.15, 1.1, 0.06, 0.01and 0.002 μM for p110α, p110β, p110δ, p110γ, DNA-PK, mTOR and PDGFR, respectively.

S2391	Quercetin(Sophoretin)	Feb 2011
Quercetin is a PI3K and PKC inhibitor with IC50 of 3.8 μM and 15µg/ml.

S1352	TG100-115	Jun 2010
TG100–115 is a PI3K γ and -δ inhibitor (IC50 = 83 and 235 nM, respectively)

S1169	TGX-221	Mar 2010
TGX-221 is a PI3Kβ(C50=10nM).

S1118	XL147	Sep 2009
XL147 is a selective inhibitor of Class I PI3K isoforms.

S1523	XL765	Oct 2010
XL765 is a mixed mTOR/PI3k inhibitor with IC50 of 157, 39, 113, 9 and 43 nM for mTOR, p110α, β, γ and δ, respectively.

S1072	ZSTK474	Jun 2009
ZSTK474 is an inhibitor of PI3K γ(IC50 at 6 nM).