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Caspase Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S7023 Z-VAD-FMK Z-VAD-FMK (Z-VAD(OMe)-FMK) is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
Nature, 2025, 10.1038/s41586-025-09222-5
Cancer Cell, 2025, S1535-6108(25)00132-1
Signal Transduct Target Ther, 2025, 10(1):341
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S2228 Belnacasan (VX-765) VX-765 (Belnacasan) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay, and it has reached Phase 2.
Signal Transduct Target Ther, 2025, 10(1):157
Haematologica, 2025, 10.3324/haematol.2025.287951
Cell Death Dis, 2025, 16(1):301
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S7312 Z-DEVD-FMK Z-DEVD-FMK (Caspase-3 Inhibitor) is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.
Protein Cell, 2025, pwaf020
EMBO Mol Med, 2025, 10.1038/s44321-025-00197-4
J Transl Med, 2025, 23(1):170
Verified customer review of Z-DEVD-FMK
S7311 Q-VD-Oph Q-VD-Oph (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9. Q-VD-OPh can inhibits HIV infection.
Nature, 2025, 10.1038/s41586-025-09754-w
Signal Transduct Target Ther, 2025, 10(1):368
Nat Immunol, 2025, 26(11):1946-1961
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S7314 Z-IETD-FMK Z-IETD-FMK (Caspase-8 Inhibitor, Z-IE(OMe)TD(OMe)-FMK) is a specific Caspase-8 inhibitor. Z-IETD-FMK is also an inhibitor of granzyme B.
Nature, 2025, 10.1038/s41586-024-08395-9
Cell Mol Immunol, 2025, 22(5):541-556
Nat Cell Biol, 2025, 27(1):59-72
Verified customer review of Z-IETD-FMK
S7775 Emricasan (IDN-6556) Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.
Nature, 2025, 10.1038/s41586-025-09741-1
Cell, 2025, S0092-8674(25)01233-4
Nat Commun, 2025, 16(1):4945
S7901 Ac-DEVD-CHO Ac-DEVD-CHO (Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO) is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2.
Proc Natl Acad Sci U S A, 2025, 122(12):e2426107122
Mater Today Bio, 2025, 34:102206
Comp Biochem Physiol C Toxicol Pharmacol, 2025, 299:110373
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S7313 Z-LEHD-FMK TFA Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival.
Nat Commun, 2025, 16(1):918
J Transl Med, 2025, 23(1):986
PLoS Pathog, 2025, 21(9):e1013491
S8102 Z-VAD(OH)-FMK Z-VAD(OH)-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.
Nat Commun, 2025, 16(1):480
Cell, 2024, 187(15):4043-4060.e30
Nat Commun, 2024, 15(1):9464
Verified customer review of Z-VAD(OH)-FMK
S8507 Z-YVAD-FMK Z-YVAD-FMK is a cell-permeable and irreversible caspase-1 specific inhibitor with anti-inflammatory and anti-tumor activities.
PLoS Pathog, 2025, 21(1):e1012915
Cancer Rep (Hoboken), 2025, 8(4):e70202
Transl Psychiatry, 2024, 14(1):166
E5825 Z-VAD Z-VAD is a competitive, irreversible pan-caspase inhibitor with broad specificity and weakly inhibits caspase-2. It induces autophagy and necrosis in irradiated breast and lung cancer models.
Cell Mol Immunol, 2025, 22(5):541-556
Cell Death Dis, 2025, 16(1):396
Sci Rep, 2025, 15(1):19413
S6846 Gly-Phe β-naphthylamide Gly-Phe β-naphthylamide (Gly-Phe beta-naphthylamide) is a substrate of cathepsin C that accumulates within the lysosome. Gly-Phe-β-naphthylamide can inhibit the cathepsin-dependent activation of caspase-8.
Acta Pharmacol Sin, 2025, 10.1038/s41401-025-01507-9
Anticancer Res, 2024, 44(9):3793-3798
E3053 Mentha Arvensis Leaf Extract Mentha Arvensis Leaf Extract is extracted from the leaf of Mentha Arvensis, which might be considered as a promising anticancer agent in breast cancer therapy in combination with synthesised GSNPs because they are less toxic and nonmutagenic and mediate caspase 9-dependent apoptosis.
E3835 Cordyceps Militaris Extract Cordyceps Militaris Extract is extracted from Cordyceps militaris, which induces apoptosis and pyroptosis via caspase-3 and can be used as an anticancer agent.
E7500 BOC-D-FMK BOC-D-FMK is a broad-spectrum inhibitor of caspase. It inhibited TNFα-stimulated apoptosis in neutrophils with an IC50 values of 39 μM.
S3275 Senkyunolide I Senkyunolide I (SEI, SENI) is an orally active compound isolated from Ligusticum chuanxiong with analgesic, anti-migraine, neuroprotective, anti-oxidation and anti-apoptosis activities. This compound up-regulates the phosphorylation of Erk1/2 and induces Nrf2 nuclear translocation with enhanced HO-1 and NQO1 expressions. It also promotes the ratio of Bcl-2/Bax and inhibits the expressions of cleaved caspase 3 and caspase 9.
Blood Sci, 2025, 7(3):e00246
iScience, 2024, 27(7):110367
World J Emerg Med, 2024, 15(3):206-213
S9042 Wedelolactone Wedelolactone, a medicinal plant-derived natural compound, is an inhibitor of IKK that is critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. This compound is also an inhibitor of caspase-11.
Int J Ophthalmol, 2024, 17(4):616-624
PeerJ, 2022, 10:e13766
Exp Eye Res, 2021, 211:108750
S9817 Ac-FLTD-CMK Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases. This compound inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. It is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively.
World J Gastroenterol, 2025, 31(36):111557
Cell Death Discov, 2024, 10(1):416
Biomolecules, 2022, 12(11)1660
S3267 Nicotiflorin (Kaempferol-3-O-rutinoside) Nicotiflorin (Kaempferol-3-O-rutinoside), a flavonoid extracted from Carthamus tinctorius, alters the shape and structure of injured neurons, decreases the number of apoptotic cells, down-regulates expression of p-JAK2, p-STAT3, caspase-3, and Bax and decreases Bax immunoredactivity, and increases Bcl-2 protein expression and immunoreactivity.
E2354 Valepotriate Valepotriate, an unstable iridoid isolated from Valeriana jatamansi Jones, has anti-epileptic by significantly increasing the expression of GABAA, glutamic acid decarboxylase 65, and Bcl-2 and reduce the expression of caspase-3.
S9075 Mulberroside A Mulberroside A, isolated from the ethanol extract of Morus alba roots, is widely employed as an active ingredient in cosmetic products due to its anti-tyrosinase and anti-oxidant activities. This compound decreases the expressions of TNF-α, IL-1β and IL-6 and inhibits the activation of NALP3, caspase-1 and NF-κB and the phosphorylation of ERK, JNK and p38.
S5579 Chelidonic acid Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxyl acid) is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals. This compound inhibits IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. It is also an inhibitor of glutamate decarboxylase with Ki of 1.2 μM.
S5584 Citronellol Citronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. This compound can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. It also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells.