Proton Pump Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S1413	Bafilomycin A1 (Baf-A1)	Bafilomycin A1 (Baf-A1) is a vacuolar H⁺-ATPase inhibitor with IC50 of 0.44 nM, and it is found to inhibit autophagy while inducing apoptosis.	Cell & Bioscience, July 05, 2025, 96 Journal of Cellular and Molecular Medicine, February 28, 2021, 3348-3360 Cells, August 09, 2025, 1231
S1389	Omeprazole	Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.	Cells, 2025 Sep 24, 1489 Gut, 2025, gutjnl-2024-334561 Gut, 2025, nan
S4845	Rabeprazole	Rabeprazole(LY307640) is an oral inhibitor of proton pump and blocks the production of acid by the stomach.	J Extracell Vesicles, 2024, 13(4):e12426 Sci Rep, 2024, 14(1):28163 Med Oncol, 2024, 41(8):188
S1354	Lansoprazole	Lansoprazole (A-65006, AG-1749) is a proton-pump inhibitor (PPI) that binds covalently to parietal cell H(+),K(+)-ATPase. This compound prevents the stomach from producing gastric acid.	Journal of Virology, May 10, 2021, e00190-21 bioRxiv, 2023, 548707 Frontiers in Cell and Developmental Biology, 2021, 655559
S3666	Ilaprazole	Ilaprazole (IY-81149) is a new proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. It inhibits H+/K+-ATPase with an IC50 of 6.0 μM.	bioRxiv, May 19, 2025, 2025.05.19.654850 Journal of Virology, May 10, 2021, 95(11):e00190-21 Journal of Virology, June 10, 2021, 95(13):e02466-20
S2105	Pantoprazole	Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.	Journal of Virology, May 10, 2021, e00190-21 Med Oncol, 2024, 41(8):188 Int J Mol Sci, 2022, 23-158572
S4665	Rabeprazole sodium	Rabeprazole (Aciphex, Dexrabeprazole, Habeprazole) is an antiulcer drug in the class of proton pump inhibitors.	Journal of Virology, 2021 May 10, e00190-21 J Virol, 2021, JVI.00190-21 Journal of Virology, 2021, e00190-21
S4099	Dexlansoprazole	Dexlansoprazole (T 168390, TAK 390,(R)-Lansoprazole), the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties. This compound selectively suppresses gastric acid secretion by direct inhibition of the H(+),K(+)-ATPase proton pump in the gastric parietal cell.	Food Chem Toxicol, 2025, 197:115262 J Immunother Cancer, 2024, 12(11)e009805 Journal of Virology, 2021, e00190-21
S5658	Omeprazole Sodium	Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion. This compound is a metabolism-dependent inhibitor (MDI) of CYP2C19.	Theranostics, 2021, 11(5):2364-2380 J Virol, 2021, JVI.00190-21 Biosci Rep, 2021, BSR20200842
S4212	Tenatoprazole	Tenatoprazole (TU-199,STU-Na) is a prodrug of the proton pump inhibitor (PPI) class, which inhibits proton transport with IC50 of 3.2 μM. This compound labels only the gastric H(+),K(+)-ATPase alpha-subunit, approximately 2.6 nM/mg of this chemical is bound to the H(+),K(+)-ATPase.	Advanced Science, 2024, e2308312 Viruses, 2024, 16(10)1566 Journal of Virology, 2021, e02466-20
S4538	Pantoprazole sodium	Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.	Journal of Virology, May 10, 2021, e00190-21 Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x J Virol, 2021, JVI.00190-21
S4075	Zinc Pyrithione	Zinc pyrithione (OM-1563) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.	Cell Chem Biol, 2021, S2451-9456(21)00213-0 Biol Reprod, 2019, 100(2):468-478 Biology of Reproduction, 2019, 468–478
S1743	Esomeprazole magnesium	Esomeprazole Magnesium(NEXIUM) is a proton pump inhibitor to reduce gastric acid secretion through inhibition of H(+)/K(+)-ATPase in gastric parietal cells.	Scientific Reports, August 17, 2017, 8491 Scientific Reports, 2017, 8491
S5885	Rabeprazole Related Compound E	Rabeprazole Related Compound E (Rabeprazole thioether) is an active metabolite of rabeprazole, which is a proton pump inhibitor.	Stem Cells Int, 2022, 2022:1396735
S5502	Ilaprazole sodium	Ilaprazole (IY-81149) sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H(+)/K(+)-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparation.	J Virol, 2021, JVI.00190-21
E6009	Esomeprazole	Esomeprazole ((S)-Omeprazole, (-)-Omeprazole) is a potent inhibitor of proton pump. It decreases acid production by inhibiting the H+, K+-ATPase enzyme in gastric parietal cells. Esomeprazole displays pharmacokinetic properties that make it more effective than omeprazole and has the potential for use in research of symptomatic gastroesophageal reflux disease.	Scientific Reports, August 17, 2017, 8491
S5058	Revaprazan Hydrochloride	Revaprazan Hydrochloride (YH1885) is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects. This compound reversibly inhibits H(+)/K(+)-ATPase via binding to the K+-binding site of the pump.	ACS Infect Dis, 2021, 10.1021/acsinfecdis.0c00754
S2222	PF-3716556	PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H⁺,K⁺-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na⁺,K⁺-ATPase, used for the treatment of gastroesophageal reflux disease.
E4878	Lansoprazole sodium	Lansoprazole Sodium, a sodium salt form of Lansoprazole, is an orally active inhibitor of proton pump, preventing the stomach from producing acid. Lansoprazole enhances the expression and transcriptional effectiveness of runt-related transcription factor 2 (Runx2), stimulating osteoprogenitor cell's commitment and differentiation toward their lineage.
S5847	Ethacrynate Sodium	Ethacrynate Sodium (ethacrynic acid sodium) is the sodium salt form of ethacrynic acid, which inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules.
S6438	Ufiprazole	Ufiprazole (Omeprazole sulfide) is an intermediate used in the production of the gastric proton pump inhibitors omeprazole and esomeprazole.
S5608	Pantoprazole sodium hydrate	Pantoprazole (BY10232, SKF96022) sodium hydrate (Protonix) is a potent inhibitor of H+/K(+)-ATPase with IC50 of 6.8 μM.	Molecular Therapy, 2025, 336-355 Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x Journal of Virology, 2021, e00190-21