CAS No. 1234480-46-6

Batch: Purity:99.66
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XMD8-87 Chemical Structure
Chemical Structure
Check the XMD8-87 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-11-methyl-5H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
CAS Number 1234480-46-6
Molecular Formula

C24H27N7O2
Molecular Weight (MW) 445.52
SMILES CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C5=CC=CC=C5C(=O)N4)C)OC
InChIKey LGLHCXISMKHLIK-UHFFFAOYSA-N

Biological Activity

XMD8-87 is a novel tyrosine kinase nonreceptor 2 (TNK2) inhibitor that targets TNK2 kinase activity. Inhibition of TNK2 modulates downstream oncogenic signaling networks, including the AKT pathway, which suppresses AKT activation and nuclear translocation. Blockade of this signaling axis disrupts cell proliferation and survival mechanisms, ultimately inhibiting cancer cell growth and survival phenotypes across TNK2-dependent cell models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 65 mg/mL (145.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Proc. Natl. Acad. Sci. U.S.A. 2010;107(52).

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Note: Technical data last updated: Sep 1, 2026.