CAS No. 1061605-21-7

Batch: Purity:99.87
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Thalidomide-O-COOH (Cereblon ligand 3) Chemical Structure
Chemical Structure
Check the Thalidomide-O-COOH (Cereblon ligand 3) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1061605-21-7
Molecular Formula

C15H12N2O7
Molecular Weight (MW) 332.27
SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)O

Ordering Information

Biological Activity

Thalidomide-O-COOH (Cereblon ligand 3) is a functionalized thalidomide derivative that acts as a ligand for the Cereblon (CRBN) E3 ubiquitin ligase. It is widely utilized as a building block in the synthesis of proteolysis targeting chimeras (PROTACs). By tethering to a target protein-binding moiety via a flexible linker, this agent recruits the CRBN E3 ligase complex to promote selective target protein ubiquitination and subsequent proteasomal degradation. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 66 mg/mL (198.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.