Simethicone SDS/MSDS (Safety Data Sheet)

3.1 Substances
Product name: Simethicone
CAS Number: 8050-81-5
PubChem CID: 6433516
Molecular formula: C6H18O4Si3
Molecular weight: 238.46 g/mol
IUPAC name: dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane

3.2 Mixtures
Not applicable (pure substance).

4.1 Description of first aid measures
Inhalation: Move to fresh air. Keep at rest in a position comfortable for breathing. Seek medical attention if symptoms persist.
Skin contact: Wash with plenty of soap and water. Remove contaminated clothing. Seek medical attention if irritation develops.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention.
Ingestion: Rinse mouth. Do NOT induce vomiting unless directed by medical personnel. Seek medical attention.

4.2 Most important symptoms and effects, both acute and delayed
See Section 11 (Toxicological Information).

4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically. Contact a poison control center or physician for severe exposure.

5.1 Extinguishing media
Suitable: Dry chemical, carbon dioxide (CO2), alcohol-resistant foam, water spray.
Unsuitable: High-pressure water jet (may spread fire).

5.2 Specific hazards arising from the substance or mixture
Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.3 Advice for firefighters
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Fight fire from upwind. Cool containers with water spray until fire is extinguished.

6.1 Personal precautions, protective equipment and emergency procedures
Wear appropriate personal protective equipment (see Section 8).
Avoid breathing dust/vapor. Ensure adequate ventilation.
Evacuate personnel to safe areas. Keep people away from and upwind of spill.

6.2 Environmental precautions
Prevent product from entering drains, waterways, or soil.
Contain spill with inert absorbent material.

6.3 Methods and materials for containment and cleaning up
ACCIDENTAL RELEASE MEASURES. Personal precautions, protective equipment and emergency procedures: Avoid dust formation. Avoid breathing vapours, mist or gas.; Environmental precautions: No special environmental precautions required.; Methods and materials for containment and cleaning up: Sweep up and shovel. Keep in suitable, closed containers for disposal.
SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.
SRP: Expired or waste pharmaceuticals shall carefully take into consideration applicable DEA, EPA, and FDA regulations. It is not appropriate to dispose by flushing the pharmaceutical down the toilet or discarding to trash. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
Appropriate engineering controls: General industrial hygiene practice.
Precautions for safe handling: Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.

7.1 Precautions for safe handling
Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids
Simethicone tablets and chewable tablets should be stored in well-closed containers at a temperature less than 40 °C, preferably between 15 - 30 °C. Simethicone oral suspension should be stored in tight, light-resistant containers at a temperature less than 40 °C, preferably between 15- 30 °C; freezing should be avoided.
Keep away from heat, sparks, and open flames. Use explosion-proof equipment.

7.2 Conditions for safe storage, including any incompatibilities
Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids
Simethicone tablets and chewable tablets should be stored in well-closed containers at a temperature less than 40 °C, preferably between 15 - 30 °C. Simethicone oral suspension should be stored in tight, light-resistant containers at a temperature less than 40 °C, preferably between 15- 30 °C; freezing should be avoided.
Store away from incompatible materials (see Section 10).
[Note: Specific storage temperature not available in public databases. Refer to supplier Certificate of Analysis (COA) for exact storage conditions.]
Store in original container. Keep upright to prevent leakage.

9.1 Information on basic physical and chemical properties
a) Appearance: Gray, translucent, viscous liquid
b) Odor: No data available
c) Odor threshold: No data available
d) pH: No data available
e) Melting point/freezing point: No data available
f) Initial boiling point and boiling range: No data available
g) Flash point: No data available
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: No data available
l) Vapor density: No data available
m) Relative density: 0.98 /Polydimethyl Silicones/
n) Water solubility: Insoluble in water
o) Partition coefficient: n-octanol/water: Log P: No data available
p) Auto-ignition temperature: No data available
q) Decomposition temperature: No data available
r) Viscosity: 60,000 centistokes
s) Explosive properties: No data available
t) Oxidizing properties: No data available

9.2 Other information
Topological Polar Surface Area (TPSA): 52.6 Ų
Complexity: 125

11.1 Information on toxicological effects
Acute toxicity:
No acute toxicity data available.
Skin corrosion/irritation:
No data available.
Serious eye damage/eye irritation:
Causes serious eye irritation (H319).
Respiratory or skin sensitization:
No data available.
Germ cell mutagenicity:
No data available.
Carcinogenicity:
No data available.
Reproductive toxicity:
No data available.
Specific target organ toxicity (single exposure):
No data available.
Specific target organ toxicity (repeated exposure):
No data available.
Aspiration hazard:
No data available.

11.2 Additional information
No additional toxicological information available.

12.1 Toxicity
LC50; Species: Daphnia magna (Water flea) age 1-48 hr, 1st instar; Conditions: freshwater, flow through, 18 °C, pH 8.8-9.3, hardness 182-204 mg/L CaCO3, alkalinity 98-99 mg/L CaCO3, dissolved oxygen 8.6-9.0 mg/L; Concentration: 245000 ug/L for 48 hr (95% confidence interval: 177000-338000 ug/L) /30% Dow Corning Antifoam A/
LC50; Species: Daphnia magna (Water flea) age 1-48 hr, 1st instar; Conditions: freshwater, flow through, 18 °C, pH 8.8-9.3, hardness 182-204 mg/L CaCO3, alkalinity 98-99 mg/L CaCO3, dissolved oxygen 8.6-9.0 mg/L; Concentration: 73400 ug/L for 48 hr (95% confidence interval: 53200-101000 ug/L) /30% Dow Corning Antifoam A/
LC50; Species: Pachygrapsus crassipes (Shore crab) length 50-80 mm; Conditions: freshwater, static, 24 °C; Concentration: >10000000 ug/L for 96 hr /30% Dow Corning Antifoam A/
LC50; Species: Penaeus sp. (Penaeidean shrimp) length 8-12 mm Penaeus oxtecus; Conditions: saltwater, static, 21 °C, salinity 27.2 ppt; Concentration: >1000000 ug/L for 96 hr /28.8% purity/
For more Ecotoxicity Values (Complete) data for Simethicone (8 total), please visit the HSDB record page.
Simethicone's production and use in personal care products such cosmetics, ointments and skin protectants(1,2), as an anti-foaming agent(1) and as an antiflatulent(1) may result in its release to the environment through various waste streams(SRC). The greatest potential source of polydimethylsiloxane fluids release to marine environments is from consumer products and process ai

12.2 Persistence and degradability
No data available.

12.3 Bioaccumulative potential
No data available.

12.4 Mobility in soil
No data available.

12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available.

12.6 Other adverse effects
No other adverse ecological effects identified.

13.1 Waste treatment methods
Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers and do not mix with other waste. Handle uncleaned containers in the same manner as the product itself.

14.1 UN number
Not regulated as dangerous goods (research quantities typically exempt).

14.2 UN proper shipping name
Not subject to transport regulations (small quantities for research use).

14.3 Transport hazard class(es)
Not classified as dangerous goods for transport (research quantities).

14.4 Packing group
Not applicable (not regulated as dangerous goods in typical research quantities).

14.5 Environmental hazards
Marine pollutant: No (not classified as environmentally hazardous per GHS).

14.6 Special precautions for user
Transport in original packaging. Ensure containers are tightly sealed.
For bulk or commercial quantities, consult applicable transport regulations (DOT, IATA, IMDG).

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
US EPA / TSCA: Subject to EPA TSCA regulations
EU ECHA / REACH: Not available in public databases.

SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
Acute (short-term) health hazard
Fire hazard

Massachusetts Right To Know Components:
This material contains components subject to the Massachusetts Right to Know Act. See Section 2 for hazard classification.
Pennsylvania Right To Know Components:
This material contains components subject to the Pennsylvania Right to Know Act. See Section 2 for hazard classification.
New Jersey Right To Know Components:
This material contains components subject to the New Jersey Right to Know Act. See Section 2 for hazard classification.

California Prop. 65 Components:
This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.

Other regulatory listings:
- The Australian Inventory of Industrial Chemicals: Chemical: Polymethylsiloxane, activated
- FDA Requirements: Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish gene

15.2 Chemical safety assessment
A chemical safety assessment has not been carried out for this substance.
For research-use-only compounds, no CSA is required under REACH Annex I.

Revision Date: 2026/09/08
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.