CAS No. 1450881-55-6
Batch:
Purity:97.24
Chemical Structure
Check the
SAR-20347
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(2-chloro-6-fluorophenyl)-5-[4-(morpholine-4-carbonyl)anilino]-1,3-oxazole-4-carboxamide | |
|---|---|---|
| CAS Number | 1450881-55-6 | |
| Molecular Formula |
C21H18ClFN4O4 |
|
| Molecular Weight (MW) | 444.84 | |
| SMILES | C1COCCN1C(=O)C2=CC=C(C=C2)NC3=C(N=C(O3)C4=C(C=CC=C4Cl)F)C(=O)N | |
| InChIKey | HEDPDFHTQKEORT-UHFFFAOYSA-N |
SAR-20347 is a potent small-molecule inhibitor of the Janus kinase family, targeting TYK2, JAK1, JAK2, and JAK3. By inhibiting TYK2 and JAK1 activity, the compound suppresses cytokine signaling pathways mediated by IL-12 and IFN-α. Blockade of these cascades inhibits downstream signal transducer and activator of transcription activation, ultimately suppressing autoimmune and inflammatory responses.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
89 mg/mL
(200.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.