CAS No. 1369773-39-6

Batch: Purity:99.93
Check CoA
Sacubitril hemicalcium salt Chemical Structure
Chemical Structure
Check the Sacubitril hemicalcium salt product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1369773-39-6
Molecular Formula

C48H56CaN2O10
Molecular Weight (MW) 861.04
SMILES [Ca++].CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC([O-])=O.CCOC(=O)C(C)CC(CC3=CC=C(C=C3)C4=CC=CC=C4)NC(=O)CCC([O-])=O

Ordering Information

Biological Activity

Sacubitril hemicalcium salt is a potent prodrug inhibitor of neprilysin (neutral endopeptidase, NEP) and a component of the dual-acting cardiovascular agent LCZ696. Following enzymatic bioactivation to its active metabolite LBQ657, it prevents the degradation of endogenous vasoactive peptides, including atrial natriuretic peptide. This inhibition enhances natriuretic peptide pathway signaling, promoting systemic vasodilation, natriuresis, and diuresis while attenuating cardiac hypertrophy and remodeling. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (116.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.