For research use only.
CAS No. 2230198-02-2
Danuglipron (PF-06882961), a non-peptide agonist, activates the canonical G protein signaling activity only in the Glucagon-like peptide-1 (GLP-1) receptor with Trp33ECD.
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Choose Selective Glucagon Receptor Inhibitors
|Description||Danuglipron (PF-06882961), a non-peptide agonist, activates the canonical G protein signaling activity only in the Glucagon-like peptide-1 (GLP-1) receptor with Trp33ECD.|
PF-06882961 stimulates cAMP accumulation in CHO cells expressing both the human and monkey GLP-1Rs with comparable EC50 values. In contrast, PF-06882961 does not increase cAMP levels in cells expressing the mouse, rat, or rabbit GLP-1R.
PF-06882961 potentiates glucose-stimulated insulin release and reduces food intake in monkeys.
|In vitro||DMSO||100 mg/mL (179.98 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04621227||Completed||Drug: PF-06882961|Drug: Rosuvastatin|Drug: Midazolam||Obesity||Pfizer||December 15 2020||Phase 1|
|NCT03538743||Completed||Drug: Placebo|Drug: PF-06882961||Type 2 Diabetes Mellitus||Pfizer||June 25 2018||Phase 1|
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