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GLP-1 Receptor

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Cat.No. Product Name Information Product Use Citations Product Validations
S9851 Danuglipron (PF-06882961) Danuglipron (PF-06882961) is a non-peptide agonist that activates the canonical G protein signaling activity only in the Glucagon-like peptide-1 (GLP-1) receptor with Trp33ECD.
S8256 Liraglutide Liraglutide is a long-acting glucagon-like peptide-1(GLP-1) receptor agonist.
Frontiers in Endocrinology, June 25, 2024, 1395028
bioRxiv, December 17, 2024, nan
Diabetes, December 1, 2025, 2375-2389
P1273New Ecnoglutide（XW003） Ecnoglutide (XW003) is a long‑acting, cAMP‑biased agonist of the glucagon‑like peptide‑1 (GLP‑1) receptor that selectively enhances cAMP signaling over β‑arrestin recruitment, and exhibits potential for the treatment of type 2 diabetes and obesity.
E1827 AZD5004 (ECC5004) ECC5004(AZD5004, GLP-1 agonist (Eccogene)) is a small molecule GLP-1 receptor agonist (GLP-1RA) used to treat digestive system diseases and endocrine and metabolic diseases. ECC5004 has the potential to be used to treat obesity, type 2 diabetes and metabolic dysfunction-associated steatohepatitis (MASH) disease.
E6682New CT-996(RO7795081，RG6652） CT‑996 (RO7795081, RG6652) is an orally active, cAMP‑biased agonist of GLP‑1R with an EC50 ≈ 0.049 nM for cAMP, with minimal β‑arrestin recruitment and receptor internalization, suitable for research on type 2 diabetes and obesity.
P1230 Retatrutide (LY3437943) Retatrutide (LY3437943) acts as a triple agonist peptide of the glucagon receptor (GCGR), glucagon-like peptide-1 receptor (GLP-1R) and glucosedependent insulinotropic polypeptide receptor (GIPR). Retatrutide binds to human GCGR, GLP-1R, and GIPR with EC50 values of 5.79, 0.775 nM, and 0.0643, respectively. Retatrutide has the potential for use in research on obesity.