SMILES:

ClC1=CC(=C(CCNC2CCN(CC2)CC3=CC=CC=C3)C=C1)Cl
NEDD8 inhibitor M22 Chemical Structure
Chemical Structure
Check the NEDD8 inhibitor M22 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-benzyl-N-[2-(2,4-dichlorophenyl)ethyl]piperidin-4-amine
CAS Number 864420-54-2
Molecular Formula

C20H24Cl2N2
Molecular Weight (MW) 363.32
SMILES ClC1=CC(=C(CCNC2CCN(CC2)CC3=CC=CC=C3)C=C1)Cl
InChIKey WMEXQHGRMWPOEF-UHFFFAOYSA-N

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 73 mg/mL (200.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 73 mg/mL
Water 4 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.