Home GPCR & G Protein Ras inhibitor LY3537982 (KRAS G12C inhibitor 19) For research use only.

LY3537982 (KRAS G12C inhibitor 19)

LY3537982 (KRAS G12C inhibitor 19) is a highly selective and potent inhibitor of the  KRAS-G12C protein. LY3537982 selectively inhibits the growth of KRAS G12C mutant cells H23 G12C, H358 G12C, and H2122 G12C with IC50s of 1.04 nM, 1.16 nM, and 11.38 nM, respectively.

LY3537982 (KRAS G12C inhibitor 19) Chemical Structure

LY3537982 (KRAS G12C inhibitor 19) Chemical Structure

CAS: 2649788-46-3

Purity & Quality Control

Batch: E143301 DMSO] 100 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.01%
99.01

LY3537982 (KRAS G12C inhibitor 19) Related Products

Signaling Pathway

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Biological Activity

Description LY3537982 (KRAS G12C inhibitor 19) is a highly selective and potent inhibitor of the  KRAS-G12C protein. LY3537982 selectively inhibits the growth of KRAS G12C mutant cells H23 G12C, H358 G12C, and H2122 G12C with IC50s of 1.04 nM, 1.16 nM, and 11.38 nM, respectively.
Targets
KRAS-G12C [1]

Chemical Information & Solubility

Molecular Weight 528.96 Formula

C25H19ClF2N4O3S
CAS No. 2649788-46-3 SDF Download LY3537982 (KRAS G12C inhibitor 19) SDF
Storage (From the date of receipt) Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

In vitro
Batch:

DMSO : 100 mg/mL ( (189.05 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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