Molecular Weight: 467.32 g/mol

Safimaltib Chemical Structure
Chemical Structure
Check the Safimaltib product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 93 mg/mL (199.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 93 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Chemical Information

IUPAC Name 1-(1-oxo-2H-isoquinolin-5-yl)-5-(trifluoromethyl)-N-[2-(trifluoromethyl)-4-pyridinyl]pyrazole-4-carboxamide
CAS Number 2230273-76-2
Molecular Formula

C20H11F6N5O2
Molecular Weight (MW) 467.32
SMILES FC(F)(F)C1=NC=CC(=C1)NC(=O)C2=C([N](N=C2)C3=CC=CC4=C3C=CNC4=O)C(F)(F)F
InChIKey APWRZPQBPCAXFP-UHFFFAOYSA-N

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Note: Technical data last updated: Sep 1, 2026.