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Icatibant Acetate

Name: Icatibant Acetate
Brand: Selleck Chemicals
SKU: S5695
Rating: 5 (1 reviews)

Synonyms: HOE-140 acetate

Catalog No.S5695 Purity: 99.90%

Icatibant Acetate(HOE-140 acetate) acts as an antagonist of the bradykinin B2 receptor and is used in the treatment of hereditary angioedema.

Icatibant Acetate Chemical Structure

CAS: 138614-30-9

Purity & Quality Control

Batch: Purity: 99.90%

99.90

Icatibant Acetate Related Products

Choose Selective Bradykinin Receptor Inhibitors

Biological Activity

Description

Icatibant Acetate(HOE-140 acetate) acts as an antagonist of the bradykinin B2 receptor and is used in the treatment of hereditary angioedema.

Targets

bradykinin B2 receptor ^[1]

In vitro
In vitro	Icatibant is a decapeptide resistant to the bradykinin-degrading proteases, resulting in a longer half-life than bradykinin which it antagonizes^[1].

In Vivo
In vivo	Icatibant exhibits efficacy in bradykinin-mediated angioedema attacks, and induces rapid symptom relief^[1].

References

[1] Charignon D, et al. Expert Opin Pharmacother. 2012, 13(15):2233-47.

Chemical Information & Solubility

Molecular Weight	1364.57	Formula	C₆₁H₉₃N₁₉O₁₅S
CAS No.	138614-30-9	SDF	--
Smiles	C1CCC2C(C1)CC(N2C(=O)C3CC4=CC=CC=C4CN3C(=O)C(CO)NC(=O)C(CC5=CC=CS5)NC(=O)CNC(=O)C6CC(CN6C(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)N)O)C(=O)NC(CCCN=C(N)N)C(=O)O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
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In vivo
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In vivo Formulation Calculator

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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