CAS No. 138614-30-9
Batch:
Purity:99.18
Chemical Structure
Check the
Icatibant Acetate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 138614-30-9 | |
|---|---|---|
| Molecular Formula |
C61H93N19O15S |
|
| Molecular Weight (MW) | 1364.57 | |
| SMILES | C1CCC2C(C1)CC(N2C(=O)C3CC4=CC=CC=C4CN3C(=O)C(CO)NC(=O)C(CC5=CC=CS5)NC(=O)CNC(=O)C6CC(CN6C(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)N)O)C(=O)NC(CCCN=C(N)N)C(=O)O |
Icatibant Acetate (HOE-140 acetate) is a potent, selective antagonist of the bradykinin B2 receptor. By blocking bradykinin binding to B2 receptors, it inhibits bradykinin-induced vasodilation, vascular permeability, and inflammatory cascades. Downstream, inhibition of B2 receptor signaling attenuates plasma extravasation and smooth muscle contraction, mitigating edema formation associated with dysregulated kallikrein-kinin pathway activation. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(73.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| DMSO |
100 mg/mL
(73.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.