CAS No. 1837-91-8

Batch: Purity:99
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1,2,3,4,5,6-Hexabromocyclohexane Chemical Structure
Chemical Structure
Check the 1,2,3,4,5,6-Hexabromocyclohexane product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1,2,3,4,5,6-hexabromocyclohexane
CAS Number 1837-91-8
Molecular Formula

C6H6Br6
Molecular Weight (MW) 557.54
SMILES C1(C(C(C(C(C1Br)Br)Br)Br)Br)Br
InChIKey QFQZKISCBJKVHI-UHFFFAOYSA-N

Ordering Information

Biological Activity

1,2,3,4,5,6-Hexabromocyclohexane (NSC7908) acts as a small-molecule inhibitor targeting Janus kinase 2 (JAK2) tyrosine kinase autophosphorylation, demonstrating potency in the low micromolar range. By suppressing target JAK2 autophosphorylation, this compound disrupts downstream JAK/STAT signaling, leading to decreased STAT transcription factor activation, altered downstream gene expression, and attenuated cell proliferation in JAK2-dependent cellular models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 5 mg/mL (8.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.