Home Angiogenesis Bcr-Abl inhibitor Flumatinib (HH-GV-678)

research use only

Flumatinib (HH-GV-678) Bcr-Abl inhibitor

Cat.No.S9973

Flumatinib (HH-GV-678) is a novel inhibitor of Bcr-Abl with IC50 values of 1.2  nM, 307.6  nM and 665.5  nM for c-Abl, PDGFRβand c-Kit, respectively.

Flumatinib (HH-GV-678) Bcr-Abl inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 562.59

Jump to

Quality Control

Batch: Purity: 99.75%
99.75

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (177.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 562.59 Formula

C29H29F3N8O

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 895519-90-1 -- Storage of Stock Solutions

Synonyms HH-GV678 Smiles CN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)C(=O)NC3=CN=C(C)C(=C3)NC4=NC(=CC=N4)C5=CN=CC=C5

Mechanism of Action

Targets/IC50/Ki
c-Abl
1.2 nM
PDGFRβ
307.6 nM
c-Kit
665.5 nM
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04933526 Recruiting
Chronic Myeloid Leukemia in Chronic Phase
Shenzhen Second People''s Hospital
 July 1 2021 Phase 4
NCT04677439 Unknown status
Flumatinib|Chronic Myeloid Leukemia Chronic Phase|Imatinib
Shenzhen Second People''s Hospital|Hainan General Hospital|Sanya Central Hospital|First Affiliated Hospital of Shantou University Medical Collegeity|Peking University Shenzhen Hospital|Dongguan People''s Hospital
 January 1 2021 Phase 4

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Signaling Pathway Map