Home JAK/STAT JAK inhibitor Delgocitinib (JTE-052)

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Delgocitinib (JTE-052) JAK inhibitor

Cat.No.S8802

Delgocitinib (JTE-052) is a specific  JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively.
Delgocitinib (JTE-052) JAK inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 310.35

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Quality Control

Batch: S880201 DMSO]62 mg/mL]false]Ethanol]6 mg/mL]false]Water]3 mg/mL]false Purity: 99.81%
99.81

Solubility

In vitro
Batch:

DMSO : 62 mg/mL (199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 6 mg/mL

Water : 3 mg/mL

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Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 310.35 Formula

C16H18N6O

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1263774-59-9 -- Storage of Stock Solutions

Synonyms N/A SMILES CC1CN(C12CCN(C2)C3=NC=NC4=C3C=CN4)C(=O)CC#N

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC50/Ki
JAK2
2.6 nM
JAK1
2.8 nM
JAK3
13 nM
TYK2
58 nM
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-26)

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NCT07203274 NOT_YET_RECRUITING
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NCT07013201 RECRUITING
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