CAS No. 1263774-59-9

Batch: Purity:99.81
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Delgocitinib (JTE-052) Chemical Structure
Chemical Structure
Check the Delgocitinib (JTE-052) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-[(3S,4R)-3-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile
CAS Number 1263774-59-9
Molecular Formula

C16H18N6O
Molecular Weight (MW) 310.35
SMILES CC1CN(C12CCN(C2)C3=NC=NC4=C3C=CN4)C(=O)CC#N
InChIKey LOWWYYZBZNSPDT-ZBEGNZNMSA-N

Ordering Information

Biological Activity

Delgocitinib (JTE-052) is a pan-Janus kinase (JAK) inhibitor targeting JAK1 (IC50 2.8 nM), JAK2 (IC50 2.6 nM), JAK3 (IC50 13 nM), and Tyk2 (IC50 58 nM). By inhibiting JAK family enzymes, delgocitinib suppresses the activation of JAK-STAT signaling pathways downstream of multiple cytokine receptors. This inhibition reduces downstream inflammatory cytokine production and immune cell activation, demonstrating broad anti-inflammatory activity in immune-mediated disease models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 62 mg/mL (199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 6 mg/mL
Water 3 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.