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garsorasib (D-1553) K-Ras inhibitor

Name: garsorasib (D-1553)
Brand: Selleck Chemicals
SKU: E1578
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E1578

Garsorasib (D-1553 ) is a potent and selective oral KRAS^G12C inhibitor with antitumor activity. It has the potential to treat KRAS G12C-mutated non-small cell lung cancer (NSCLC).

Chemical Structure

Molecular Weight: 598.65

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Quality Control

Batch: E157801 DMSO]100 mg/mL]false]Ethanol]3 mg/mL]false]Water]Insoluble]false Purity: 99.07%

Cited in Nature Medicine for its top-tier quality
COA
HPLC
SDS
Datasheet

99.07

Related Targets	CXCR Hedgehog/Smoothened PKA Adrenergic Receptor AChR 5-HT Receptor Histamine Receptor Dopamine Receptor Ras GPR
Other K-Ras Products	Adagrasib (MRTX849) MRTX1133 BI-2852 RMC-7977 HRS-4642 Daraxonrasib (RMC-6236) Zoldonrasib (RMC-9805) ARS-1620 ARS-853 BI-3406

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (167.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (8.35mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.550mg/ml (0.92mM)	Taking the 1 mL working solution as an example, add 50 μL of 11 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	598.65	Formula	C₃₂H₃₂F₂N₈O₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	2559761-14-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

Targets/IC₅₀/Ki	KRAS-G12C
References	[1] https://pubmed.ncbi.nlm.nih.gov/36948246/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06233916	Completed	Mass Balance Study	InventisBio Co. Ltd	December 8 2023	Phase 1
NCT06105255	Active not recruiting	Healthy Male	InventisBio Co. Ltd	May 24 2023	Phase 1
NCT06166836	Recruiting	Solid Tumor	InxMed (Shanghai) Co. Ltd.\|InventisBio Co. Ltd	October 12 2022	Phase 1\|Phase 2
NCT05492045	Recruiting	NSCLC	InventisBio Co. Ltd	September 13 2022	Phase 1\|Phase 2
NCT05383898	Active not recruiting	NSCLC	InventisBio Co. Ltd	March 16 2021	Phase 1\|Phase 2

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Handling Instructions

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