CAS No. 2866179-95-3

Batch: Purity:99.40
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Bleximenib oxalate Chemical Structure
Chemical Structure
Check the Bleximenib oxalate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-ethyl-5-fluoro-2-[[5-[2-[(3R)-6-[2-methoxyethyl(methyl)amino]-2-methylhexan-3-yl]-2,7-diazaspiro[3.4]octan-7-yl]-1,2,4-triazin-6-yl]oxy]-N-propan-2-ylbenzamide;oxalic acid
CAS Number 2866179-95-3
Molecular Formula

C32H50FN7O3.C2H2O4
Molecular Weight (MW) 689.83
InChIKey OYKHOVACUSUKFI-HZPIKELBSA-N

Ordering Information

Biological Activity

Bleximenib oxalate is a small-molecule inhibitor targeting the menin-mixed-lineage leukemia 1 (menin-MLL) interaction. By disrupting the binding between menin and MLL, it alters chromatin accessibility and downregulates key downstream leukemogenic target gene expression, including HOXA9 and MEIS1. This disruption subsequently suppresses leukemia cell proliferation, blocks cell cycle progression, and promotes differentiation in MLL-rearranged cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (144.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.