p53 Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S8149	NSC348884	NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.	Mol Cell, 2025, S1097-2765(25)00409-5 Front Immunol, 2022, 13:956991 Nat Commun, 2020, 3;11(1):1669
S8000	Tenovin-1	Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. This compound is also an inhibitor of dihydroorotate dehydrogenase (DHODH).	J Pharm Biomed Anal, 2021, 201:114121 J Transl Med, 2019, 17(1):76 Int J Mol Med, 2019, 44(3):1091-1105
S4900	Tenovin-6	Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). This compound is also an inhibitor of SirT1 and SirT2.	Cell Death Dis, 2023, 14(10):667 Front Immunol, 2021, 12:685523 Biomed Pharmacother, 2020, 125:109948
S8106	NSC59984	NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.	Cancers (Basel), 2023, 15(3)745 J Clin Med, 2023, 12(23)7491 Front Bioeng Biotechnol, 2020, 8:538663
S8580	COTI-2	COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.	Biometals, 2025, 10.1007/s10534-025-00736-z J Cell Mol Med, 2024, 28(9):e18374 DASH, 2020, None
S5791	Cyclic Pifithrin-α hydrobromide	Cyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53.	Front Pharmacol, 2022, 13:926317 Clin Transl Med, 2020, 10.1002/ctm2.41
S8187	ReACp53	ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC).	PNAS Nexus, 2022, 1(3):pgac128 Nat Commun, 2021, 12(1):3962
S5811	Kevetrin hydrochloride	Kevetrin hydrochloride (Thioureidobutyronitrile) is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.	Int J Mol Sci, 2022, 23(17)10042
E2943	Pifithrin-β	Pifithrin-β (PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide) is a potent inhibitor of p53 with an IC50 of 23 μM and is regarded as a lead compound for cancer and neurodegenerative disease therapy.	Biol Reprod, 2025, ioaf113
S9235	Didymin	Didymin (Neoponcirin, Isosakuranetin-7-O-rutinoside) is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture. It possesses antioxidant, anti-inflammation and anti-cancer properties.
E1971	Rezatapopt	Rezatapopt(PC14586) is a first-in-class p53 reactivator. It selectively binds to the mutated p53 Y220C protein and restores its wild-type activity. It can also be used to inhibit solid tumor with p53 mutation.
E0935	MS7972	MS7972 is a small molecule that blocks human p53 and CREB binding protein association.
E0035	CP-31398 Dihydrochloride	CP-31398 Dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
E7154	C16-Ceramide	C16-Ceramide (N-Palmitoylsphingosine)is a sphingolipid ligand and an activator of p53 tumor suppressor. It tightly binds within the p53 DNA-binding domain with a Kd of ~ 60 nM, in close vicinity to the Box V motif. It regulates the protein ubiquitination and proteasomal degradation and also induces apoptosis in cancer cells making it a research tool for targeting human cancers.
E1735	PK11007	PK11007 is a thiol-reactive anticancer agent that stabilizes p53 via selective alkylation of two surface cysteines without compromising its DNA binding. It induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels.
S9488	Lobetyolin	Lobetyolin is one of the important active ingredients extracted from the root of Codonopsis pilosula, which has a good protective effect on gastric mucosal damage. This compound can downregulate glutamine metabolism, contribute to drug-induced apoptosis and tumor growth inhibition, and it significantly reduces the mRNA and protein expression of the amino acid transporter alanine-serine-cysteine transporter 2 (ASCT2).
S8728	PK11000	PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.
S2427	Triglycidyl Isocyanurate (Teroxirone)	Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. This compound alkylates and cross-links DNA, thereby inhibiting DNA replication. It is also used in various polyester powder coatings in the metal finishing industry.
S2341	(-)-Parthenolide	(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.	J Adv Res, 2025, S2090-1232(25)00353-4 Biomed Pharmacother, 2025, 188:118183 Cell Death Discov, 2025, 11(1):286
S7649	SAR405838	SAR405838 is an orally available MDM2 antagonist with K_i of 0.88 nM. This compound is a diastereomer of MI-773 (CAS: 1303607-07-9). Phase 1.	Nat Genet, 2025, 57(1):140-153 Pharmaceutics, 2023, 15(4)1274 bioRxiv, 2023, 10.1101/2023.03.10.531074
S0507	CBL0137	CBL0137 (Curaxin-137) is an inhibitor of the histone chaperone FACT (facilitates chromatin transcription) that simultaneously suppresses NF-κB and activates p53 with EC50 of 0.47 μM and 0.37 μM, respectively.	Cancer Med, 2024, 13(20):e70288 STAR Protoc, 2024, 5(4):103446 JCI Insight, 2023, 8(4)e154120
S2678	NSC 207895	NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.	PLoS One, 2024, 19(1):e0295629 Front Oncol, 2021, 11:582511 Genes Dev, 2020, 34(7-8):526-543
E3037	Solanum lyratum Extract	Solanum lyratum Extract (300 μg/ml) increases Bax levels and decreases Bcl-2 levels, which cause the loss of mitochondrial membrane potential (Δæm) followed by cytochrome C release and caspase-9 and -3 activation, finally leading to apoptosis. This compound also promotes p53 and p27, but decreases the levels of cyclin B1 thus causing S-phase arrest.
S2176	Tenovin-3	Tenovin-3 is an inhibitor of SIRT2. This compound is able to increase p53 levels in MCF-7 cells.
S6882	HI-TOPK-032	HI-TOPK-032 is a potent and specific inhibitor of TOPK. This compound also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.
E0068	NiCur	NiCur is a small molecule which blocks CREB-binding protein (CBP) histone acetyltransferase (HAT) activity and downregulates p53 activation upon genotoxic stress and diminishs the recruitment of p53 as well as RNA Polymerase II and levels of acetylation on histone H3 on CDKN1A promoter.
E0394	YK 3-237	YK-3-237, a SIRT1 activator, reduces acetylation of mutant p53 and inhibits the proliferation of triple-negative breast cancer cells.
S6851	RA-190	RA190, a bis-benzylidine piperidon, is a potent, selective and oral effective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1 with anticancer activity. RA190 triggers ER stress response, p53/p21 signaling axis and autophagy in multiple myeloma cells.