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Norepinephrine Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S3199 Reboxetine mesylate Reboxetine (PNU 155950E) is a norepinephrine reuptake inhibitor with Ki of 8.2 nM.
Cancer Discov, 2020, CD-20-0160
Micromachines (Basel), 2018, 9(6)E274
S2084 Duloxetine HCl Duloxetine HCl (LY-248686) is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
Cancers (Basel), 2022, 14(19)4883
Drug Metab Dispos, 2015, 44(3):378-88
J Pharmacol Exp Ther, 2014, 349(3):402-7
Verified customer review of Duloxetine HCl
S3183 Amitriptyline HCl Amitriptyline HCl is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. This compound also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. It is a tricyclic antidepressant (TCA).
Environ Toxicol Chem, 2021, 10.1002/etc.5018
PLoS Pathog, 2020, 16;16(3):e1008341
Sci Rep, 2018, 8(1):15753
S2541 Clomipramine HCl Clomipramine HCl is a tricyclic antidepressant acting as a potent inhibitor of 5-HT reuptake with an IC50 value of 1.5 nM. Clomipramine hydrochloride is used in research on depression, anxiety, and obsessive-compulsive disorder (OCD).
Biomed Pharmacother, 2022, 153:113328
bioRxiv, 2020, 2020/9/20.4.7.30734
S4113 Desvenlafaxine Desvenlafaxine (WY 45233 Succinate) is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.
Am J Cancer Res, 2024, 14(3):1087-1100
Drug Metab Dispos, 2020, 48(10):1044-1052
S5947 Amitriptyline Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. This compound is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. It also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid.
Cancer Cell, 2025, 43(4):776-796.e14
Cancers (Basel), 2019, 11(12)
S3140 Milnacipran HCl Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively.
Am J Cancer Res, 2024, 14(3):1087-1100
S3698 Nortriptyline hydrochloride Nortriptyline hydrochloride (Desitriptyline, ELF-101, EN-7048, Desmethylamitriptyline) is the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression.
Front Bioinform, 2021, 1:710591
S4112 Desvenlafaxine Succinate hydrate Desvenlafaxine Succinate hydrate (WY 45233) is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.
Drug Metab Dispos, 2020, 48(10):1044-1052
S3175 Atomoxetine HCl Atomoxetine (LY 139603) is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.
Cell Commun Signal, 2024, 22(1):532
S0318 Ansofaxine hydrochloride Ansofaxine hydrochloride (LY03005, LPM570065), a triple reuptake inhibitor, inhibits serotonin, dopamine and norepinephrine reuptake with IC50 values of 723, 491 and 763 nM, respectively.
S5496 Guanethidine Monosulfate Guanethidine monosulfate is an antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves.
E4898 Escitalopram Escitalopram ((S)-Citalopram), (S)-+ Citalopram)) is a selective serotonin reuptake inhibitor (SSRI) with a Ki value of 0.89 nM. This compound has approximately 30-fold higher binding affinity than its R(-)-enantiomer and exhibits selectivity over both norepinephrine transporter (NET) and dopamine transporter (DAT).