Home Neuronal Signaling Norepinephrine

Norepinephrine Antagonists

Cat.No. Product Name Information Product Use Citations Product Validations
S1444 Ziprasidone HCl Ziprasidone HCl (CP-88059) is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder.
UNIVERSITY OF PÉCS, 2023,
Anticancer Res, 2021, 41(2):687-697
Molecules, 2020, 25(18)E4206
Verified customer review of Ziprasidone HCl
S2517 Maprotiline HCl Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.
Ann Hematol, 2025, 10.1007/s00277-025-06571-z
Front Pharmacol, 2021, 12:689767
S3044 Lurasidone HCl Lurasidone (SM-13496) is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively.
Alzheimers Dement, 2023, 10.1002/alz.13090
E4952 Nefazodone Nefazodone is a selective antagonist of 5-HT2Areceptors and moderately inhibits serotonin and norepinephrine reuptake, enhancing 5-HT synaptic transmission. It is also a potent inhibitor of CYP3A4 with reduced anticholinergic, alpha-adrenolytic, and sedative effects, along with notable immunoprotective properties.
E4840 Ziprasidone hydrochloride monohydrate Ziprasidone hydrochloride monohydrate is an antipsychotic drug, a combined antagonist of 5-HT (serotonin) and dopamine receptor. It exhibits binding affinities for D2, 5-HT2A, 5-HT1A with Ki values 4.8 nM, 0.42 nM, 3.4 nM respectively.
S5664 Orphenadrine Hydrochloride Orphenadrine Hydrochloride is an uncompetitive NMDAR antagonist, H1 receptor antagonist and nonselective mAChR antagonist with muscle relaxant activity.
S3120 Doxepin HCl Doxepin is a tricyclic antidepressant formulated as a mixture of E-(trans) and Z-(cis) stereoisomers. It inhibits CYP2D6 activity in vivo.
E4930 Asenapine Asenapine(Org 5222, HSDB8061) is a multi-target receptor antagonist. It acts as an antagonist of serotonin receptors with pKi values of 8.4-10.5, adrenoceptors with pKi values of 8.9-9.5, dopamine receptors with pKi values of 8.9-9.4 and histamine receptors with pKi values of 8.2-9.0.