| S4701 |
2-DG (2-Deoxy-D-glucose)
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2-DG (2-Deoxy-D-glucose), an analog of glucose, is a glycolytic inhibitor with antiviral activity. 2-Deoxy-D-glucose induces apoptosis and inhibits Herpes Simplex Virus type-1 (HSV-1) receptor expression.
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Signal Transduct Target Ther, 2025, 10(1):341
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Nat Commun, 2025, 16(1):212
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Cancer Commun (Lond), 2025, 10.1002/cac2.70036
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| S8047 |
Dynasore
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Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM in a cell-free assay, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase. Dynasore suppresses mTORC1 activity and induces autophagy. Dynasore inhibits the entry of several viruses, including herpes simplex virus (HSV).
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J Nanobiotechnology, 2025, 23(1):173
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Cell Death Dis, 2025, 16(1):681
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Blood Adv, 2025, bloodadvances.2024015296
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| S8428 |
FSL-1
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FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.
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| S9070 |
(2S)-(-)-isoxanthohumol
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(2S)-(-)-isoxanthohumol is one of the most important prenylflavonoids found in hops. It exhibits an antiproliferative activity against human breast cancer cell lines, ovarian cancer, prostate cancer, and colon cancer cells. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV).
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| S7546 |
Pritelivir (BAY 57-1293)
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Pritelivir (BAY 57-1293, AIC316) is a potent helicase primase inhibitor that exhibits antiviral effects on herpes simplex virus (HSV), with an IC50 of 20 nM for both HSV-1 and HSV-2.
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PLoS Pathog, 2021, 17(11):e1010117
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J Virol, 2021, JVI0166621
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