Beta Amyloid Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S9428	Brazilin	Brazilin (Natural Red 24) is a red pigment obtained from the wood of the brazilwood family. It is used to dye fabric and has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.	J Cell Mol Med, 2025, 29(13):e70688
E2948	β-Amyloid (25-35)	β-Amyloid (25-35) (Amyloid beta-peptide (25-35), Aβ25-35, β-Amyloid peptide (25-35)) is a highly toxic synthetic derivative of Amyloid beta-peptide (Aβ-peptides) which forms fibrillary aggregates. This compound, with the sequence GSNKGAIIGLM, is involved in the pathogenesis of Alzheimer's disease.
E3560	Incised notopterygium rhizome Extract	Incised Notopterygium Rhizome Extract is extracted from Notopterygium incisum, which rescues cognitive deficits in APP/PS1 Alzheimer's disease mice by attenuating amyloid-beta, tau, and neuroinflammation pathology.
S0529	PBD-150	PBD-150 is a potent human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor with Ki of 60 nM.
S5101	Tabersonine hydrochloride	Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.
E0077	Simufilam	Simufilam(PTI-125) is a potent, orally active small drug against AD, which interacts to filamin and controls the actin cytoskeleton. This compound reduces tau hyperphosphorylation, amyloid and tau formation by preventing and reversing the binding of Aβ42 to α7 nAChR.
S6733	Edonerpic maleate	Edonerpic maleate (T-817) is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).
S2418	Frentizole	Frentizole (Frentizol) is a novel inhibitor of amyloid beta peptide (Abeta) binding alcohol dehydrogenase (ABAD) interaction with IC50 of 200 μM. This compound is a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus.
S3405	CRANAD-2	CRANAD-2, a near-infrared (NIR) Amyloid-beta (Aβ) plaque-specific fluorescent probe, penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM.
S2660	MK-0752	MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2.	Nat Cell Biol, 2024, 26(3):353-365 Cancers (Basel), 2023, 15(6)1883 J Cancer Res Clin Oncol, 2023, 149(16):14691-14699
S1594	Semagacestat (LY450139)	Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. It also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. This compound has reached Phase 3 clinical trials.	Cell Rep Med, 2025, S2666-3791(25)00102-8 Biochim Biophys Acta Mol Basis Dis, 2025, 1871(8):167992 Cancers (Basel), 2023, 15(6)1883
S1262	Avagacestat (BMS-708163)	Avagacestat (BMS-708163) is a potent, selective, and orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 values of 0.3 nM and 0.27 nM, respectively. This compound demonstrates a 193-fold selectivity against Notch and has reached Phase 2 clinical trials.	Nat Commun, 2022, 13(1):6345 Sci Rep, 2022, 12(1):7 Cell, 2021, 184(2):521-533.e14
S1528	LY2811376	LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.	Journal of Agricultural and Food Chemistry, January 27, 2022, 1536-1546 Journal of Cell Biology, February 04, 2019, 644-663 Alzheimers & Dementia, August 12, 2019, 1183-1194
S9664	Colivelin	Colivelin (CLN) is a brain-penetrant neuroprotective peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.	J Clin Invest, 2025, 135(11)e181243 J Adv Res, 2025, S2090-1232(25)00444-8 Stem Cell Res Ther, 2025, 16(1):40
S4760	(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD)	(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD, HP-β-cyclodextrin, Hydroxypropyl betadex, Hydroxypropyl-β-cyclodextrin) is a well-known sugar used in drug delivery, genetic vectors, environmental protection, and the treatment of Niemann-Pick disease type C1 (NPC1). It is an inhibitor of amyloid-β aggregation and widely used drug delivery vehicle to improve stability and bioavailability.	Journal of Cancer, March 28, 2022, 2126-2137 bioRxiv , 2023, 10.1101/2023.07.14.548985 Technol Cancer Res Treat, 2021, 20:15330338211027916