STING Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
E0128	C-171	C-171 is a covalent small-molecule inhibitor of STING. This compound efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING.	Cell Reports, 2023, 112328 Cell Rep, 2023, 42(4):112328
S8954	G10 (STING agonist-1)	G10 (STING agonist-1) is a novel human-specific STING agonist that triggers IFN regulatory factor 3 (IRF3)/ type I interferon (IFN)-associated transcription in human fibroblasts. This compound potently reduces growth of Chikungunya virus (CHIKV) with IC90 of 8.01 μM and blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM.	Int J Biol Sci, 2023, 19(11):3428-3440
E1787	SN-001	SN-001 is a potent inhibitor of STING that specifically inhibits STING activation and STING-dependent signaling. SN-011 significantly decreases inflammatory cytokine production and osteoclast formation in vivo.
E5921^New	ZSA-51	ZSA-51 is a potent oral agonist of STING. It exhibits potent antitumor efficacy in colon and pancreatic cancer, with superior oral PK, low toxicity, and immune microenvironment remodeling in tumors and lymph nodes.
S9618	E7766 diammonium salt	E7766 diammonium salt, a macrocycle-bridged _STING agonist with a Kd of 40 nM, shows potent pan-genotypic and antitumor activities.
E1881	NVS-STG2	NVS-STG2(HY-157214) is a potent, allosteric small molecule agonist of STING. It binds at the transmembrane domain (TMD) interface of STING, thereby acting as a molecular glue to promote STING oligomerization and contribute to its activation. It may be used in research of STING-related autoimmune diseases.
E1835	diABZI STING agonist-1 trihydrochloride	diABZI STING agonist-1 trihydrochloride is a selective stimulator of the interferon genes STING receptor, acting as an agonist with EC50 of 130 nM for human STING and 186 nM for mouse STING.
S7905	3',3'-cGAMP	3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.
E2664	Cridanimod	Cridanimod, a low-Mw interferon-inducer (IFN-inducer), recognizes the intracellular signaling protein stimulator of interferon genes (STING), resulting in the STING-TBK1-IRF3 pathway activation and synthesis of type I IFNs (subtypes IFN-α and IFN-β).
E0127	C-170	C-170 is a covalent small-molecule inhibitor of STING. This compound efficiently inhibits both hsSTING and mmSTING through the same covalent modification with C-171.
S1113	GSK690693	GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1.	Theranostics, 2025, 15(18):9819-9837 Cell Rep, 2025, 44(7):115947 Front Cell Infect Microbiol, 2025, 15:1543186
S3804	Alpha-Mangostin	Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.	Int J Mol Sci, 2024, 25(13)7378 Front Pharmacol, 2021, 12:692806