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STING Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
E0128 C-171

C-171 is a covalent small-molecule inhibitor of STING. This compound efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING.
Cell Reports, 2023, 112328
Cell Rep, 2023, 42(4):112328
E1787 SN-001 SN-001 is a potent inhibitor of STING that specifically inhibits STING activation and STING-dependent signaling. SN-011 significantly decreases inflammatory cytokine production and osteoclast formation in vivo.
S0544New STING agonist-3 STING agonist-3 (example 10), is a selective and non-nucleotide agonist of STING with a pEC50 and pIC50 of 7.5 and 9.5, respectively.
E5921New ZSA-51 ZSA-51 is a potent oral agonist of STING. It exhibits potent antitumor efficacy in colon and pancreatic cancer, with superior oral PK, low toxicity, and immune microenvironment remodeling in tumors and lymph nodes.
S9618 E7766 diammonium salt E7766 diammonium salt, a macrocycle-bridged STING agonist with a Kd of 40 nM, shows potent pan-genotypic and antitumor activities.
E1881 NVS-STG2 NVS-STG2(HY-157214) is a potent, allosteric small molecule agonist of STING. It binds at the transmembrane domain (TMD) interface of STING, thereby acting as a molecular glue to promote STING oligomerization and contribute to its activation. It may be used in research of STING-related autoimmune diseases.
E1835 diABZI STING agonist-1 trihydrochloride diABZI STING agonist-1 trihydrochloride is a selective stimulator of the interferon genes STING receptor, acting as an agonist with EC50 of 130 nM for human STING and 186 nM for mouse STING.
S7905 3',3'-cGAMP 3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.
E2664 Cridanimod Cridanimod, a low-Mw interferon-inducer (IFN-inducer), recognizes the intracellular signaling protein stimulator of interferon genes (STING), resulting in the STING-TBK1-IRF3 pathway activation and synthesis of type I IFNs (subtypes IFN-α and IFN-β).
E0127 C-170

C-170 is a covalent small-molecule inhibitor of STING. This compound efficiently inhibits both hsSTING and mmSTING through the same covalent modification with C-171.
S1113 GSK690693 GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1.
Theranostics, 2025, 15(18):9819-9837
Cell Rep, 2025, 44(7):115947
Front Cell Infect Microbiol, 2025, 15:1543186
Verified customer review of GSK690693
S6494 CCCP (Carbonyl cyanide 3-chlorophenylhydrazone) CCCP (Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone), an oxidative phosphorylation inhibitor, is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP), the protonophore, can inhibits STING-mediated IFN-β production via disrupting mitochondrial membrane potential (MMP).
Mol Cell, 2025, 85(7):1467-1476.e6
Life Sci, 2025, 380:123965
iScience, 2025, 28(8):112972
S3804 Alpha-Mangostin Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.
Int J Mol Sci, 2024, 25(13)7378
Front Pharmacol, 2021, 12:692806