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STING Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S6575 C-176 STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway.
Nat Commun, 2025, 16(1):289
J Clin Invest, 2025, e193945
MedComm (2020), 2025, 6(10):e70411
S6494 CCCP CCCP (Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone), an oxidative phosphorylation inhibitor, is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential. This compound, the protonophore, can inhibits STING-mediated IFN-β production via disrupting mitochondrial membrane potential (MMP).
Mol Cell, 2025, 85(7):1467-1476.e6
Life Sci, 2025, 380:123965
iScience, 2025, 28(8):112972
S6667 STING inhibitor C-178 C-178 is a covalent inhibitor of STING,covalently bind to Cys91.
Nature, 2025, 647(8090):735-746
Neurosci Lett, 2025, 847:138095
Research Square, 2023, Version 2
E0128 C-171

C-171 is a covalent small-molecule inhibitor of STING. This compound efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING.
Cell Reports, 2023, 112328
Cell Rep, 2023, 42(4):112328
E1787 SN-001 SN-001 is a potent inhibitor of STING that specifically inhibits STING activation and STING-dependent signaling. SN-011 significantly decreases inflammatory cytokine production and osteoclast formation in vivo.
E0127 C-170

C-170 is a covalent small-molecule inhibitor of STING. This compound efficiently inhibits both hsSTING and mmSTING through the same covalent modification with C-171.
S1113 GSK690693 GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1.
Theranostics, 2025, 15(18):9819-9837
Cell Rep, 2025, 44(7):115947
Front Cell Infect Microbiol, 2025, 15:1543186
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