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PPAR Activators

Cat.No. Product Name Information Product Use Citations Product Validations
S8029 WY-14643 (Pirinixic Acid) WY-14643 (Pirinixic Acid, NSC 310038) is a potent and selective PPARα activator with an EC50 of 1.5 μM.
Mol Med, 2025, 31(1):153
Int J Mol Sci, 2025, 26(3)1051
Front Pharmacol, 2024, 15:1366479
Verified customer review of WY-14643 (Pirinixic Acid)
S4708 Palmitoylethanolamide Palmitoylethanolamide (PEA, Palmidrol, N-palmitoylethanolamine) is an endogenous fatty acid amide and selectively activates PPAR-α in vitro with an EC50 value of 3.1±0.4 μM.
Nature Communications, September 19, 2024, 8221
Nature Communications, December 2, 2021, 7031
iMetaOmics, 2026, e70078
S1849 Daidzein Daidzein is a natural isoflavone phytoestrogen found in Leguminosae, used as a component of foods and dietary supplements. This compound is a soy isoflavone, which acts as a PPAR activator.
Communications Medicine, 2025, 420
Communications Medicine, 2025, 5(1)
Ecotoxicol Environ Saf, 2024, 275:116262
S3290 Procyanidin B2 (PCB2) Procyanidin B2 (PCB2), a natural flavonoid found in commonly consumed foods, possess anti-inflammatory, anti-oxidant and anti-cancer activities. It activates PPARγ to induce M2 polarization in mouse macrophages and significantly suppresses the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model.
BMC Cardiovasc Disord, 2024, 24(1):231
BMC Cardiovascular Disorders, 2024, 231
Front Pharmacol, 2021, 12:639651
S3875 Alpinetin Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. This compound is a flavonoid isolated from Alpinia katsumadai Hayata, activates PPAR-γ, with potent anti-inflammatory activity.
CNS Neuroscience & Therapeutics, 2024, e70676
Nutrients, 2021, 3382
Nutrients, 2021, 13(10)3382
S1729 Gemfibrozil Gemfibrozil (CI-719) is an activator of peroxisome proliferator-activated receptor-alpha (PPARα), used for the treatment of hypercholesterolemia and hypertriglyceridemia.
J Immunother Cancer, 2024, 12(11)e009805
bioRxiv, 2023, 2023.07.12.548707
S9189 Oroxin A Oroxin A (Baicalein 7-O-glucoside), an active component isolated from the herb Oroxylum indicum (L.) Kurz, activates PPARγ and inhibits α-glucosidase, exerting antioxidant activity.
Front Pharmacol, 2022, 13:894899
An Acad Bras Cienc, 2022, 94(suppl 4):e20211400
S9177 Gypenoside XLIX Gypenoside XLIX, a naturally occurring gynosaponin, is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator.
Chin Med, 2024, 19(1):70
Am J Transl Res, 2023, 15(2):834-846
S5121 Phytol Phytol (Trans-Phytol), a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.
E3521 Auricledleaf Swallowwort Root Extract Auricledleaf Swallowwort Root Extract is obtained from Cynanchum otophyllum Schneid., which may be mediated by activation of PPARα and TFEB, and the subsequent autophagy-lysosomal pathway enhancement, thus attenuate Alzheimer’s disease pathology and improve cognitive function in 3XTg mice.
S5851 4'-Methoxychalcone 4'-Methoxychalcone, found in citrus, is chalcone derivative that has shown diverse pharmacological properties, including anti-tumor and anti-inflammatory activities. This compound significantly enhanced adipocyte differentiation, in part, by its potent effects on PPARγ activation and by its reverse effect on TNF-α.
S9723 CDDO-Im (RTA-403) An activator of nuclear factor erythroid 2–related factor 2 (Nrf2) and peroxisome proliferator-activated receptor (PPAR), CDDO-Im (RTA-403) binds to PPARα and PPARγ with Ki of 232 nM and 344 nM, respectively. It inhibits inflammatory response and tumor growth in vivo.
Ecotoxicol Environ Saf, 2022, 241:113754
International Journal of Molecular Sciences, 2022, 11715
Int J Mol Sci, 2022, 23(19)11715
E0473 CUDA CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively, also selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity.