PPAR Activators

Cat.No.	Product Name	Information	Product Use Citations
S8029	WY-14643 (Pirinixic Acid)	WY-14643 (Pirinixic Acid, NSC 310038) is a potent and selective PPARα activator with an EC50 of 1.5 μM.	Mol Med, 2025, 31(1):153 Int J Mol Sci, 2025, 26(3)1051 Front Pharmacol, 2024, 15:1366479
S4708	Palmitoylethanolamide	Palmitoylethanolamide (PEA, Palmidrol, N-palmitoylethanolamine) is an endogenous fatty acid amide and selectively activates PPAR-α in vitro with an EC50 value of 3.1±0.4 μM.	Nat Commun, 2024, 15(1):8221 Neurosci Insights, 2020, 15:2633105520975412 J Steroid Biochem Mol Biol, 2019, 10.1016/j.jsbmb.2018.07.005
S1849	Daidzein	Daidzein is a natural isoflavone phytoestrogen found in Leguminosae, used as a component of foods and dietary supplements. This compound is a soy isoflavone, which acts as a PPAR activator.	Ecotoxicol Environ Saf, 2024, 275:116262 J Mol Neurosci, 2018, 64(2):211-223
S9189	Oroxin A	Oroxin A (Baicalein 7-O-glucoside), an active component isolated from the herb Oroxylum indicum (L.) Kurz, activates PPARγ and inhibits α-glucosidase, exerting antioxidant activity.	Front Pharmacol, 2022, 13:894899 An Acad Bras Cienc, 2022, 94(suppl 4):e20211400
S3290	Procyanidin B2 (PCB2)	Procyanidin B2 (PCB2), a natural flavonoid found in commonly consumed foods, possess anti-inflammatory, anti-oxidant and anti-cancer activities. It activates PPARγ to induce M2 polarization in mouse macrophages and significantly suppresses the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model.	BMC Cardiovasc Disord, 2024, 24(1):231 Front Pharmacol, 2021, 12:639651
S9177	Gypenoside XLIX	Gypenoside XLIX, a naturally occurring gynosaponin, is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator.	Chin Med, 2024, 19(1):70 Am J Transl Res, 2023, 15(2):834-846
S1729	Gemfibrozil	Gemfibrozil (CI-719) is an activator of peroxisome proliferator-activated receptor-alpha (PPARα), used for the treatment of hypercholesterolemia and hypertriglyceridemia.	J Immunother Cancer, 2024, 12(11)e009805
S3875	Alpinetin	Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. This compound is a flavonoid isolated from Alpinia katsumadai Hayata, activates PPAR-γ, with potent anti-inflammatory activity.	Nutrients, 2021, 13(10)3382
S5121	Phytol	Phytol (Trans-Phytol), a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.
E3521	Auricledleaf Swallowwort Root Extract	Auricledleaf Swallowwort Root Extract is obtained from Cynanchum otophyllum Schneid., which may be mediated by activation of PPARα and TFEB, and the subsequent autophagy-lysosomal pathway enhancement, thus attenuate Alzheimer’s disease pathology and improve cognitive function in 3XTg mice.
S5851	4'-Methoxychalcone	4'-Methoxychalcone, found in citrus, is chalcone derivative that has shown diverse pharmacological properties, including anti-tumor and anti-inflammatory activities. This compound significantly enhanced adipocyte differentiation, in part, by its potent effects on PPARγ activation and by its reverse effect on TNF-α.
S9723	CDDO-Im (RTA-403)	An activator of nuclear factor erythroid 2–related factor 2 (Nrf2) and peroxisome proliferator-activated receptor (PPAR), CDDO-Im (RTA-403) binds to PPARα and PPARγ with Ki of 232 nM and 344 nM, respectively. It inhibits inflammatory response and tumor growth in vivo.	Ecotoxicol Environ Saf, 2022, 241:113754 Int J Mol Sci, 2022, 23(19)11715
E0473	CUDA	CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively, also selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity.