PDHK

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Catalog No. Product Name Information Product Use Citations Product Validations
S7517 AZD7545 AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. It failed to inhibit PDHK4 at higher concentrations(>10 nM), AZD7545 stimulates PDHK4 activity.
Mol Cell, 2021, 81(4):691-707.e6
Mol Cell, 2020, S1097-2765(20)30904-7
Nat Commun, 2020, 11(1):4684
S7517 AZD7545 AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. It failed to inhibit PDHK4 at higher concentrations(>10 nM), AZD7545 stimulates PDHK4 activity.
Mol Cell, 2021, 81(4):691-707.e6
Mol Cell, 2020, S1097-2765(20)30904-7
Nat Commun, 2020, 11(1):4684