PDHK

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S4299	Dicoumarol	Dicoumarol is a competitive NADPH quinone oxidoreductase (NQO1) inhibitor,and used as an anticoagulant by interfering with the metabolism of vitamin K.	Adv Sci (Weinh), 2025, 12(7):e2411538 Redox Biol, 2024, 75:103292 Redox Biology, 2024, 103292
S7517	AZD7545	AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. It failed to inhibit PDHK4 at higher concentrations(>10 nM), this compound stimulates PDHK4 activity.	Journal of Translational Medicine, 2025, Article number: 1256 Human Molecular Genetics, 2024, 12-32 Sci Rep, 2023, 13(1):8776

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S4299

Dicoumarol

Dicoumarol is a competitive NADPH quinone oxidoreductase (NQO1) inhibitor,and used as an anticoagulant by interfering with the metabolism of vitamin K.

Adv Sci (Weinh), 2025, 12(7):e2411538

Redox Biol, 2024, 75:103292

Redox Biology, 2024, 103292

S7517

AZD7545

AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. It failed to inhibit PDHK4 at higher concentrations(>10 nM), this compound stimulates PDHK4 activity.

Journal of Translational Medicine, 2025, Article number: 1256

Human Molecular Genetics, 2024, 12-32

Sci Rep, 2023, 13(1):8776