P-gp Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
E0080	UCLA GP130 2	UCLA GP130 2 (GP130 receptor agonist-1) is a potent, brain-penetrant and orally active Glycoprotein 130 (Gp130) receptor agonist, being a humanin mimetic binding to the GP130 D4-D5 domain and reducing NMDA-induced toxicity.
S9201	Levistilide A	Levistilide A (Diligustilide), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.
S9563	Evodine	Evodine, a natural product extracted from Evodiae fructus (EF), is a biomarker for quality assessment of EF in the Chinese Pharmacopoeia. This compound is a potent P-gp inhibitor.
E1742	Reversan	Reversan (CBLC4H10) is a selective and nontoxic inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp), with the potential to treat neuroblastoma and other MRP1-overexpressing drug-refractory tumors.
S4202	Verapamil HCl	Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.	Cancer Cell, 2025, 43(4):776-796.e14 Nat Commun, 2025, 16(1):7115 Blood Sci, 2025, 7(2):e00236
S7124	SC144	SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.	Cell Rep Med, 2025, S2666-3791(25)00102-8 Respir Res, 2025, 26(1):285 bioRxiv, 2025, 2025.01.20.633954
S3600	Schisandrin B	Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.	Phytomedicine, 2025, 141:156672 Front Pharmacol, 2025, 16:1547685 Sci Rep, 2025, 15(1):8452
S4662	Atazanavir	Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. This compound is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.	Int J Mol Sci, 2022, 23(23)15380 Chemistry, 2022, e202202798. Cells, 2021, 10(12)3458
E4980	Verapamil	Verapamil(Iproveratril,Dilacoran), is a phenylalkylamine derivative which is an antagonist of calcium influx and also an inhibitor P-gp and CYP3A4. It exhibits potency in treatment for angina, cardiac arrhythmias, cardiomyopathies and hypertension.	Nat Commun, 2025, 16(1):8069 J Am Heart Assoc, 2025, 14(1):e037400 Pharmaceuticals (Basel), 2025, 18(2)181