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CFTR Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S6003 Ataluren (PTC124) Ataluren (PTC124) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM in HEK293 cells, and may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation). This compound is currently in Phase 3.
Int J Mol Med, 2025, 55(5)69
Stem Cell Reports, 2022, 17(10):2187-2202
Int J Mol Sci, 2022, 23(7)3541
Verified customer review of Ataluren (PTC124)
S7139 CFTRinh-172 CFTRinh-172 (CFTR inhibitor 172) is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.
Mol Ther Nucleic Acids, 2025, 36(4):102756
J Cyst Fibros, 2025, S1569-1993(25)01612-1
Nat Cancer, 2024, 10.1038/s43018-024-00731-2
Verified customer review of CFTRinh-172
S8094 GlyH-101 GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM.
mBio, 2023, 14(5):e0151623
Cell Mol Immunol, 2020, 10.1038/s41423-020-0499-3
S7329 IOWH032 IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 2.
Sci Rep, 2023, 13(1):3934
S0198 PPQ-102 PPQ-102 (CFTR Inhibitor IV) is a potent inhibitor of CFTR. This compound can completely inhibit CFTR chloride current with IC50 of ~90 nM.
Cells, 2023, 12(5)776
S3272 Steviol (Hydroxydehydrostevic acid) Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902), a major metabolite of the sweetening compound stevioside, inhibits CFTR activity, reduces AQP2 expression and promotes AQP2 degradation.