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CFTR Modulators

Cat.No. Product Name Information Product Use Citations Product Validations
S1565 VX-809 (Lumacaftor) Lumacaftor (VX-809, VRT 826809) acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation,EC50 of 0.1 μM in fisher rat thyroid cells. Phase 3.
Nucleic Acids Res, 2025, 53(13)gkaf675
Br J Pharmacol, 2025, 10.1111/bph.70176
iScience, 2025, 28(3):111942
Verified customer review of VX-809 (Lumacaftor)
S8851 VX-445 (Elexacaftor) Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector.This is a compound which is not chiral purity.
Nucleic Acids Res, 2025, 53(13)gkaf675
Mol Ther Nucleic Acids, 2025, 36(4):102756
Cell Mol Life Sci, 2025, 82(1):109
S8795 FDL169 FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.
Cell Mol Gastroenterol Hepatol, 2021, S2352-345X(21)00158-2
J Pers Med, 2021, 11(7)643
JCI Insight, 2020, 5(18)139983
S8535 Galicaftor (ABBV-2222) Galicaftor (ABBV-2222, GLPG2222) is a potent corrector of CFTR for the treatment of Cystic Fibrosis (CF).
Front Pharmacol, 2024, 15:1494327
Biology, 2022, (182)-
J Vis Exp, 2022, (182)
E1743 Deutivacaftor (VX-561, Ivacaftor-D9) VX-561 (CTP-656) is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE cells.
S6599 KM11060 KM11060 is a small molecule that corrects the processing of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation.