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CFTR Activators

Cat.No. Product Name Information Product Use Citations Product Validations
S8698 GLPG1837 GLPG1837 (ABBV-974) is a novel CFTR potentiator with an EC50 value of 3 nM for F508del, showing enhanced efficacy on CFTR mutants harboring class III mutations compared to Ivacaftor.
Cell Mol Life Sci, 2024, 81(1):426
iScience, 2022, 25(1):103710
Int J Mol Sci, 2022, 23(18)10758
S6911 Nesolicaftor (PTI-428) Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression.