Molecular Weight(MW): 303.4
Vildagliptin (LAF-237) inhibits DPP−4 with IC50 of 2.3 nM.
Purity & Quality Control
Choose Selective DPP-4 Inhibitors
|Description||Vildagliptin (LAF-237) inhibits DPP−4 with IC50 of 2.3 nM.|
Vildagliptin is the most stable DPP-IV inhibitor, binding in the S1- and S2-catalytic sites of DPP-IV, possessing a P-1 site transition-state mimetic. 
|In vivo||Vildagliptin(orally dosed with 10 μmol/kg) is a potent, orally active inhibitor of plasma DPP-IV activity that provides increased levels of GLP-1 in an oral glucose tolerance test (OGTT) with Obese male Zucker rats. Vildagliptin orally dosed with 10 μmol/kg both significantly decreases glucose excursions and stimulates insulin secretion in Obese male Zucker rats. Maximum inhibition of plasma DPP-IV activity (95%) is observed approximately 2 hours postdose of Vildagliptin (1 μmol/kg, po) while >50% inhibition of DPP-IV is observed within 30 min postdose and persisted for >10 hours in normal Cynomolgus monkeys.  Vildagliptin(60 mg/kg) increases pancreatic beta cell mass through enhanced beta cell replication and reduced apoptosis, and the increased beta cell mass is sustained for 12 days after vildagliptin washout.  Vildagliptin administrated at doses of 10 mg/kg for 32 weeks protects nerve fiber loss in streptozotocin (STZ)-induced diabetic adult male Sprague Dawley rats. |
|In vitro||DMSO||60 mg/mL (197.75 mM)|
|Water||60 mg/mL (197.75 mM)|
|Ethanol||60 mg/mL (197.75 mM)|
|In vivo||Add solvents individually and in order:
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02849899||Not yet recruiting||Disorder Related to Renal Transplantation|Diabetes||Centre Hospitalier Universitaire de Besancon|University Hospital, Tours|University Hospital, Lille|Recherche Clinique Paris Descartes Necker Cochin Sainte Anne|Amiens University Hospital|University Hospital, Brest|Rennes University Hospital|Tenon Hospital, Paris|Centre Hospitalier Universitaire de Nice|University Hospital, Strasbourg, France||January 2017||Phase 3|
|NCT02803892||Recruiting||Diabetes Mellitus, Type 1||Piemonti Lorenzo|Fondazione Italiana Diabete Onlus|Ospedale San Raffaele||May 2016||Phase 2|
|NCT02999841||Recruiting||Diabetes Mellitus, Type 2|Obesity||Peking University||March 2016||Phase 4|
|NCT02475070||Recruiting||Type 2 Diabetes||Lund University||January 2016||Phase 4|
|NCT02832999||Recruiting||Type 2 Diabetes Mellitus||Yaounde Central Hospital|University of Yaounde 1|University of Buea||January 2016||Phase 4|
|NCT02343926||Completed||Type 2 Diabetes Mellitus||Sanofi||December 2014||Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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