ONO-4059 analogue

Catalog No.S7877 Synonyms: ONO-WG-307

ONO-4059 analogue Chemical Structure

Molecular Weight(MW): 456.50

ONO-4059 analogue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.

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Biological Activity

Description ONO-4059 analogue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.
Targets
BTK [1]
23.9 nM
In vitro

In TMD-8 cells, ONO-4059 inhibits cell growth with IC50 of 3.59 nM, and induces cell apoptosis. The combination of of ONO-4059 with doxorubicin, etoposide, vincristine or dexamethasone causes the increased apoptosis ratio. [1]

Protocol

Solubility (25°C)

In vitro DMSO 20 mg/mL warmed (43.81 mM)
Water Insoluble
Ethanol Insoluble warmed

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 456.50
Formula

C25H24N6O3

CAS No. 1351635-67-0
Storage powder
in solvent
Synonyms ONO-WG-307

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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BTK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID