Home Angiogenesis BTK inhibitor CNX-774 For research use only.

CNX-774

CNX-774 is an irreversible, orally active, and highly selective BTK inhibitor with IC50 of <1 nM.

CNX-774 Chemical Structure

CNX-774 Chemical Structure

CAS: 1202759-32-7

Selleck's CNX-774 has been cited by 5 Publications

1 Customer Review

Purity & Quality Control

Batch: S725701 DMSO] 100 mg/mL] false] Ethanol] 2 mg/mL] false] Water] Insoluble] false Purity: 99.67%
99.67

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Signaling Pathway

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Biological Activity

Description CNX-774 is an irreversible, orally active, and highly selective BTK inhibitor with IC50 of <1 nM.
Features Orally bioavailable BTK-selective inhibitor, binding covalently to target protein.
Targets
BTK [1]
<1 nM
In vitro
In vitro In cellular assays, CNX-774 demonstrates potent inhibitory activity towards BTK with IC50 of 1-10 nM by targeting Cys-481 residue within the ATP binding site of the enzyme. [1]

Chemical Information & Solubility

Molecular Weight 499.5 Formula

C26H22FN7O3
CAS No. 1202759-32-7 SDF Download CNX-774 SDF
Smiles CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)F
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (200.2 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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