PLK

  • Compare PLK Inhibitors
  • Research Area

PLK Inhibitors (7)

water-soluble

Cat.No. Product Name Information Product Citations Customer Reviews
S1109 BI 2536 BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
  • Cell, 2011, 4(10):1087-96
  • Cancer Cell, 2010, 18(6):641-54
  • Nat Cell Biol, 2011, 13(10):1265-71
S2235 Volasertib (BI 6727) BI6727 (Volasertib) is a highly potent Plk1 inhibitor with IC50 of 0.87 nM. It shows 6- and 65-fold greater selectivity against Plk2 and Plk3. Phase 2.
  • Cancer Res, 2013, 73(20):6310-22
  • Oncogene, 2013, 10.1038/onc.2013.518
  • PLoS One, 2013, 8(10):e77053
S2193 GSK461364 GSK461364 inhibits purified Plk1 with Ki of 2.2 nM. It is more than 1000-fold selective against Plk2/3. Phase 1.
  • Cancer Res, 2013, 73(20):6310-22
  • Br J Pharmacol, 2012, 166(3):858-76
  • PLoS One, 2013, 8(10):e77053
S1362 Rigosertib (ON-01910) Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Phase 3.
  • Cancer Res, 2013, 73(20):6310-22
  • Stem Cells, 2013, 31(6):1051-63
  • PLoS One, 2013, 8(11):e79863
S2898 MLN0905 MLN0905 is a potent inhibitor of PLK1 with IC50 of 2 nM.
S7248 Ro3280 RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.
S1485 HMN-214 HMN-214 is a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1.