HCV Protease

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HCV Protease Inhibitors (5)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1482 Daclatasvir (BMS-790052) Daclatasvir (BMS-790052) is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture. Phase 3.
  • Nature, 2013, 501(7466):237-41
  • Hepatology, 2014, 10.1002/hep.27197
  • PLoS Pathog, 2015, 11(3):e1004758
S1538 Telaprevir (VX-950) Telaprevir (VX-950) is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35 μM.
  • Hepatology, 2014, 60(6):1838-50
  • Antimicrob Agents Chemother, 2014, 59(1):599-608
  • Antimicrob Agents Chemother, 2014, 58(6):3206-16
S1480 VX-222 (VCH-222, Lomibuvir) VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L. Phase 2.
  • Biochem Pharmacol, 2015, 96(3):190-201
  • Antimicrob Agents Chemother, 2014, 59(1):599-608
  • Antimicrob Agents Chemother, 2014, 58(6):3206-16
S1183 Danoprevir (ITMN-191) Danoprevir(ITMN-191) is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM, inhibition effect for HCV genotypes 1A/1B/4/5/6 is ~10-fold higher than 2B/3A. Phase 2.
  • Mol Biol Evol, 2014, 31(6):1546-53
  • Antimicrob Agents Chemother, 2015, 10.1128/AAC.00223-15
  • Antimicrob Agents Chemother, 2014, 58(9):5386-94
S7579 Ledipasvir (GS5885) Ledipasvir (GS5885) is a HCV NS5A polymerase inhibitor, used for the treatment of hepatitis C virus infection.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1482 Daclatasvir (BMS-790052) <1 mg/mL 148 mg/mL 148 mg/mL
S1538 Telaprevir (VX-950) <1 mg/mL 136 mg/mL <1 mg/mL
S1480 VX-222 (VCH-222, Lomibuvir) <1 mg/mL 89 mg/mL 89 mg/mL
S1183 Danoprevir (ITMN-191) <1 mg/mL 144 mg/mL 144 mg/mL
S7579 Ledipasvir (GS5885) <1 mg/mL 100 mg/mL 100 mg/mL
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