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TEAD Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
E1598 VT103 VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation with anti-proliferative and anti-tumor activity. It also inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation and disrupts interaction between YAP/TAZ and TEAD.
E1884 HC-258 HC-258 is a covalent acrylamide inhibitor of TEAD that reduces the CTGF, CYR61, AXL, and NF2 transcript levels and inhibits the migration of MDA-MB-231 breast cancer cells.
S8164 YAP-TEAD Inhibitor 1 (Peptide 17) YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.
Adv Sci (Weinh), 2025, 12(36):e09361
EMBO Mol Med, 2025, 10.1038/s44321-025-00278-4
Stem Cell Res Ther, 2025, 16(1):489
Verified customer review of YAP-TEAD Inhibitor 1 (Peptide 17)
S8554 Super-TDU Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.
Matrix Biol, 2024, S0945-053X(24)00107-0
Gut Microbes, 2023, 15(1):2192501
Cell Death Discov, 2023, 9(1):424
S8951 TED-347 TED-347 is a potent, irreversible, covalent and allosteric inhibitor of the TEAD⋅Yap protein-protein interaction. This compound inhibits TEAD4⋅Yap1 protein-protein interaction with an apparent EC50 of 5.9 μM.
Viruses, 2025, 17(3)400
Aging Cell, 2023, e13913.
Sci Adv, 2023, 9(28):eadf9460