CB1 Selective Agonists | Antagonists
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
|S8012||Otenabant (CP-945598) HCl||
Otenabant (CP-945598) HCl is a potent and selective cannabinoid receptor CB1 antagonist with Ki of 0.7 nM, exhibits 10,000-fold greater selectivity against human CB2 receptor. Phase 1.
|Selective||rCB1, Ki: 2.8 nM; hCB1, Ki: 0.7 nM|
Rimonabant is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane.
|Selective||hCB1, IC50: 13.6 nM|
AM251 block the inhibitory effects of endocannabinoids and synthetic cannabinoid agonists on transmitter release through an action at presynaptic cannabinoid 1 receptors in brain.
Org 27569 is an allosteric modulator of cannabinoid CB1 receptor, induces a CB1 receptor state that is characterized by enhanced agonist affinity and decreased inverse agonist affinity.
AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
|Pan||CB1, Ki: 280 nM|
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