Home Ubiquitin USP inhibitor USP5-IN-1

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USP5-IN-1 USP inhibitor

Cat.No.E6603

USP5-IN-1 (compound 64) is a selective competitive inhibitor targeting the zinc finger ubiquitin-binding domain (ZnF-UBD) of USP5, exhibiting a dissociation constant (KD) of 2.8 μM. This compound competitively inhibits ubiquitin binding to ZnF-UBD, suppresses USP5 catalytic activity, and consequently impedes ubiquitin chain hydrolysis. In vitro studies demonstrate its ability to inhibit USP5-mediated cleavage of Lys48-linked diubiquitin substrates, positioning it as both a potential chemical probe for USP5 and a candidate therapeutic agent for USP5-associated cancers.
USP5-IN-1 USP inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 437.90

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Chemical Information, Storage & Stability

Molecular Weight 437.90 Formula

C19H20ClN3O5S

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CAS No. 2851040-81-6 Download SDF Storage of Stock Solutions

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