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USP Inhibitors

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Cat.No. Product Name Information Product Use Citations Product Validations
E6603New USP5-IN-1 USP5-IN-1 (compound 64) is a selective competitive inhibitor targeting the zinc finger ubiquitin-binding domain (ZnF-UBD) of USP5, exhibiting a dissociation constant (KD) of 2.8 μM. This compound competitively inhibits ubiquitin binding to ZnF-UBD, suppresses USP5 catalytic activity, and consequently impedes ubiquitin chain hydrolysis. In vitro studies demonstrate its ability to inhibit USP5-mediated cleavage of Lys48-linked diubiquitin substrates, positioning it as both a potential chemical probe for USP5 and a candidate therapeutic agent for USP5-associated cancers.
E6603New USP5-IN-1 USP5-IN-1 (compound 64) is a selective competitive inhibitor targeting the zinc finger ubiquitin-binding domain (ZnF-UBD) of USP5, exhibiting a dissociation constant (KD) of 2.8 μM. This compound competitively inhibits ubiquitin binding to ZnF-UBD, suppresses USP5 catalytic activity, and consequently impedes ubiquitin chain hydrolysis. In vitro studies demonstrate its ability to inhibit USP5-mediated cleavage of Lys48-linked diubiquitin substrates, positioning it as both a potential chemical probe for USP5 and a candidate therapeutic agent for USP5-associated cancers.
E6603New USP5-IN-1 USP5-IN-1 (compound 64) is a selective competitive inhibitor targeting the zinc finger ubiquitin-binding domain (ZnF-UBD) of USP5, exhibiting a dissociation constant (KD) of 2.8 μM. This compound competitively inhibits ubiquitin binding to ZnF-UBD, suppresses USP5 catalytic activity, and consequently impedes ubiquitin chain hydrolysis. In vitro studies demonstrate its ability to inhibit USP5-mediated cleavage of Lys48-linked diubiquitin substrates, positioning it as both a potential chemical probe for USP5 and a candidate therapeutic agent for USP5-associated cancers.