CAS No. 696655-62-6
Batch:
Purity:98.90
Chemical Structure
Check the
NPD8733
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-(4-methoxybenzoyl)-1-benzofuran-3-yl]acetamide | |
|---|---|---|
| CAS Number | 696655-62-6 | |
| Molecular Formula |
C18H15NO4
|
|
| Molecular Weight (MW) | 309.32 | |
| SMILES | COC1=CC=C(C=C1)C(=O)C2=C(NC(C)=O)C3=CC=CC=C3O2 | |
| InChIKey | NQZBUYPGHZTWIR-UHFFFAOYSA-N |
NPD8733 is a small-molecule inhibitor of cancer cell-enhanced fibroblast migration that specifically binds to valosin-containing protein (VCP)/p97, a member of the AAA+ ATPase family. By targeting VCP/p97, NPD8733 disrupts p97-mediated protein quality control and cellular homeostasis pathways. Consequently, this targeted inhibition suppresses cancer-stimulated stromal cell motility and reduces fibroblast migration within the tumor microenvironment, highlighting p97 as a key regulator of tumor-stroma interactions. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
31 mg/mL
(100.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.