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Divarasib (GDC-6036) KRAS G12C Inhibitor

Name: Divarasib (GDC-6036)
Brand: Selleck Chemicals
SKU: E1187
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E1187

Divarasib (GDC-6036, RG6330) is a KRAS G12C inhibitor that binds irreversibly to switch II pocket of KRAS G12C (when in the inactive GDP-bound state) thereby blocking GTP binding and activation.

Divarasib (GDC-6036) KRas inhibitor Chemical Structure

Quality Control

Batch: E118701 DMSO]100 mg/mL]false]Ethanol]100 mg/mL]false]Water]Insoluble]false Purity: 99.62%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS/MSDS
Datasheet

99.62

Related Targets	ERK p38 MAPK Raf JNK MEK Ras S6 Kinase MAP4K TAK1 Mixed Lineage Kinase
Other KRas Inhibitors	RMC-7977 Daraxonrasib (RMC-6236) MRTX1133 Zoldonrasib (RMC-9805) BI-2852 Adagrasib (MRTX849) HRS-4642 ARS-1620 BI-3406 ARS-853

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (160.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	622.06	Formula	C₂₉H₃₂ClF₄N₇O₂	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	2417987-45-0	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

Targets/IC₅₀/Ki	KRAS G12C
References	[1] https://pubmed.ncbi.nlm.nih.gov/36083155/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-09-02)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05862285	RECRUITING	Cancer	Hoffmann-La Roche	2023-06-01	PHASE3
NCT04589845	ACTIVE_NOT_RECRUITING	Solid Tumors	Hoffmann-La Roche	2021-01-18	PHASE2
NCT07541170	RECRUITING	Non-small Cell Lung Cancer	Hoffmann-La Roche	2026-09-01	PHASE3
NCT05789082	RECRUITING	Non-Small Cell Lung Cancer	Hoffmann-La Roche	2023-06-20	PHASE1; PHASE2
NCT04929223	RECRUITING	Metastatic Colorectal Cancer	Hoffmann-La Roche	2021-10-22	PHASE1
NCT06793215	RECRUITING	Non-Small Cell Lung Cancer; KRAS G12C Lung Cancer	Hoffmann-La Roche	2025-10-24	PHASE3

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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