CAS No. 2417987-45-0
Batch:
Purity:99.62
Chemical Structure
Check the
Divarasib (GDC-6036)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1-[(3S)-4-[7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]quinazolin-4-yl]-3-methylpiperazin-1-yl]prop-2-en-1-one | |
|---|---|---|
| CAS Number | 2417987-45-0 | |
| Molecular Formula |
C29H32ClF4N7O2 |
|
| Molecular Weight (MW) | 622.06 | |
| InChIKey | ZRBPIAWWRPFDPY-IRXDYDNUSA-N |
Biological Activity
Divarasib (GDC-6036) is an orally available, potent covalent inhibitor of KRAS G12C that irreversibly binds to the switch II pocket of the inactive GDP-bound protein, thereby blocking GTP binding and oncogenic activation. Target inhibition impairs downstream MAPK signaling through the RAF/MEK/ERK pathway, resulting in suppressed cellular proliferation and robust tumor growth inhibition across multiple KRAS G12C-positive cancer cell lines and models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(160.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.