Rimegepant (BMS-927711)

Catalog No.S6659 Synonyms: BHV-3000

For research use only.

Rimegepant (BMS-927711, BHV-3000) is a potent, selective, competitive human calcitonin gene-related peptide (CGRP) receptor antagonist with ki of 0.027 nM.

Rimegepant (BMS-927711) Chemical Structure

CAS No. 1289023-67-1

Purity & Quality Control

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Biological Activity

Description Rimegepant (BMS-927711, BHV-3000) is a potent, selective, competitive human calcitonin gene-related peptide (CGRP) receptor antagonist with ki of 0.027 nM.
Targets
CGRP receptor [1]
(Cell-free assay)
0.027 nM(Ki)

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 534.56
Formula

C28H28F2N6O3

CAS No. 1289023-67-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CC(C2=C(C=CC=N2)C(C1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05399485 Not yet recruiting Drug: Rimegepant|Drug: Placebo Migraine Biohaven Pharmaceuticals Inc. July 31 2022 Phase 3
NCT05371652 Recruiting Drug: Rimegepant 75mg Orally Disintegrating Tablets (ODT) Acute Migraine Biohaven Pharmaceuticals Inc.|Bioshin (Shanghai) Consulting Services Co. Ltd May 19 2022 Phase 3
NCT05262517 Recruiting Drug: Rimegepant|Drug: Placebo Temporomandibular Disorders (TMD) Biohaven Pharmaceuticals Inc.|Biohaven Pharmaceutical Holding Company Ltd. May 5 2022 Phase 2|Phase 3
NCT05248997 Recruiting Drug: rimegepant 75 mg ODT|Drug: Matching placebo Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps Biohaven Pharmaceuticals Inc.|Biohaven Pharmaceutical Holding Company Ltd. February 17 2022 Phase 2|Phase 3
NCT05156398 Recruiting Drug: Rimegepant|Drug: Placebo Migraine Biohaven Pharmaceuticals Inc.|Biohaven Pharmaceutical Holding Company Ltd. February 28 2022 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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