CAS No. 2055597-12-9
Batch:
Purity:99.05
Chemical Structure
Check the
ASN007
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-(oxan-4-ylamino)pyrimidin-4-yl]imidazole-4-carboxamide | |
|---|---|---|
| CAS Number | 2055597-12-9 | |
| Molecular Formula |
C22H25ClFN7O2 |
|
| Molecular Weight (MW) | 473.93 | |
| SMILES | CC1=CN=C(NC2CCOCC2)N=C1[N]3C=NC(=C3)C(=O)NC(CN)C4=CC(=CC(=C4)F)Cl | |
| InChIKey | PWHIUQBBGPGFFV-GOSISDBHSA-N |
ASN007 is an orally active, potent inhibitor of ERK1/2. By targeting ERK1/2 within the MAPK signaling cascade, this compound inhibits downstream phosphorylation events necessary for tumor cell proliferation and survival. Disruption of ERK signaling blocks oncogenic signaling pathways, making it particularly useful in research investigating cancers driven by RAS mutations and aberrant MAPK pathway reactivation. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
95 mg/mL
(200.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 95 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.